MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.3.36	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; phosphoinositide 5-phosphatase
3.1.3.56	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; inositol-polyphosphate 5-phosphatase
3.1.3.86	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Structure

PDB	Resolution (Å)	PDB name
2YSX		Solution structure of the human SHIP SH2 domain
5RW2	1.22	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2737076969
5RW3	1.37	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2064898339
5RW4	1.31	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z19735192
5RW5	1.38	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z69092635
5RW6	1.32	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434816
5RW7	1.23	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z86622311
5RW8	1.27	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z28290384
5RW9	1.45	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z203581214
5RWA	1.29	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434812
5RWB	1.25	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434899
5RWC	1.4	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434879
5RWD	1.29	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1675346324
5RWE	1.34	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434865
5RWF	1.35	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1983897532
5RWG	1.46	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990
5RWH	1.56	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1152242726
5RWI	1.29	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434926
5RWJ	1.26	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434824
5RWK	1.32	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1267881672
5RWL	1.37	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1348371854
5RWM	1.36	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z136583524
5RWN	1.38	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1310876699
5RWO	1.29	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434898
5RWP	1.48	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z915492990
5RWQ	1.32	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z44592329
5RWR	1.43	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434783
5RWS	1.28	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1478435544
5RWT	1.43	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z32327641
5RWU	1.37	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z57778470
5RWV	1.25	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1103351268
5RWW	1.16	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2241115980
5RWX	1.34	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z44567722
5RWY	1.35	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1259335913
5RWZ	1.42	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z57299529
5RX0	1.43	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z57258487
5RX1	1.31	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2466069494
5RX2	1.27	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1827898537
5RX3	1.45	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1262327505
5RX4	1.35	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1593306637
5RX5	1.28	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2443429438
5RX6	1.45	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z30620520
5RX7	1.36	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1545196403
5RX8	1.34	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434884
5RX9	1.29	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z54226095
5RXA	1.24	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434829
5RXB	1.58	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434821
5RXC	1.59	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434868
5RXD	1.33	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z111810692
5RXE	1.25	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z240654968
5RXF	1.26	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2074076908
5RXG	1.52	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434909
5RXH	1.42	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z939944666
5RXI	1.74	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2447286438
5RXJ	1.52	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1722836661
5RXK	1.46	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434840
5RXL	1.49	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1673618163
5RXM	1.46	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434894
5RXO	1.71	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z68299550
5RXP	1.53	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434944
5RXQ	1.65	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z26548083
5RXR	1.4	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1148747945
5RXS	1.37	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1818332938
5RXT	1.63	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z319545618
5RXU	1.64	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434858
5RXV	1.5	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z45527714
5RXW	1.34	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434856
5RXX	1.43	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1275599911
5RXY	1.4	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z32014663
5RXZ	1.56	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z19739650
5RY0	1.98	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z275165822
5RY1	1.52	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2940170964
5RY2	1.54	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z19727416
5RY3	1.5	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2027158783
5RY4	1.47	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z300245038
5RY5	1.54	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z166605480
5RY6	1.74	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z198194394
5RY7	1.6	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1267773591
5RY8	1.43	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1374778753
5RY9	1.52	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z274575916
5RYA	1.32	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1741973467
5RYB	1.55	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z927400026
5RYC	1.56	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z18197050
5RYD	1.6	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z955369596
5RYE	1.7	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z33545544
5RYF	1.49	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1266823232
5RYG	1.47	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z168883358
5RYH	1.72	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1212984951
5RYI	1.45	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z274555794
5RYJ	1.42	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2177153697
5RYK	1.55	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1346370629
5RYL	1.55	INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1745658474
6IBD	1.48	The Phosphatase and C2 domains of Human SHIP1
6XY7	1.086	Human SHIP1 with magnesium and phosphate bound to the active site

GO term

GO ontology	GO term	GO description
Biological Process	GO:0050852	T cell receptor signaling pathway
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0008340	determination of adult lifespan
Biological Process	GO:0016064	immunoglobulin mediated immune response
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0030889	negative regulation of B cell proliferation
Biological Process	GO:0045779	negative regulation of bone resorption
Biological Process	GO:0050777	negative regulation of immune response
Biological Process	GO:0032715	negative regulation of interleukin-6 production
Biological Process	GO:0045656	negative regulation of monocyte differentiation
Biological Process	GO:0045659	negative regulation of neutrophil differentiation
Biological Process	GO:0045671	negative regulation of osteoclast differentiation
Biological Process	GO:0009968	negative regulation of signal transduction
Biological Process	GO:0006796	phosphate-containing compound metabolic process
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation
Biological Process	GO:0045579	positive regulation of B cell differentiation
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation
Biological Process	GO:0050776	regulation of immune response
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0017124	SH3 domain binding
Molecular Function	GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Molecular Function	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity
Molecular Function	GO:0004445	inositol-polyphosphate 5-phosphatase activity
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
Molecular Function	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
Molecular Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR000300	Inositol polyphosphate-related phosphatase
IPR000980	SH2 domain
IPR005135	Endonuclease/exonuclease/phosphatase
IPR036691	Endonuclease/exonuclease/phosphatase superfamily
IPR036860	SH2 domain superfamily

Pfam	Pfam name
PF00017	SH2 domain
PF03372	Endonuclease/Exonuclease/phosphatase family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	Leaf	R-HSA-1430728	Metabolism
R-HSA-202424	Downstream TCR signaling	Leaf	R-HSA-168256	Immune System
R-HSA-210990	PECAM1 interactions	Leaf	R-HSA-109582	Hemostasis
R-HSA-912526	Interleukin receptor SHC signaling	Leaf	R-HSA-168256	Immune System
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000250
Cytoplasm	ECO:0000269	PubMed:10822173
Cytoplasm, cytoskeleton	ECO:0000250
Membrane	ECO:0000269	PubMed:10822173
Membrane raft	ECO:0000250

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Enhanced
appendix	germinal center cells	High	Enhanced
appendix	non-germinal center cells	High	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	glandular cells	Low	Enhanced
caudate	glial cells	Low	Enhanced
cerebellum	granular cells - cytoplasm/membrane	High	Enhanced
cerebellum	molecular layer cells - cytoplasm/membrane	High	Enhanced
cerebellum	processes in molecular layer	High	Enhanced
cerebellum	processes in white matter	High	Enhanced
cerebellum	white matter cells - cytoplasm/membrane	High	Enhanced
cerebral cortex	glial cells	Low	Enhanced
colon	mucosal lymphoid cells	High	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 2	cells in endometrial stroma	Low	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
hippocampus	glial cells	Low	Enhanced
kidney	proximal tubules (microvilli)	High	Enhanced
lung	alveolar cells type I	Medium	Enhanced
lymph node	germinal center cells	High	Enhanced
lymph node	non-germinal center cells	High	Enhanced
ovary	ovarian stroma cells	Low	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
rectum	endothelial cells	Low	Enhanced
rectum	mucosal lymphoid cells	High	Enhanced
salivary gland	glandular cells	Medium	Enhanced
skeletal muscle	myocytes	Low	Enhanced
soft tissue 1	peripheral nerve	Low	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	High	Enhanced
thyroid gland	glandular cells	Low	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced

Summary of Q92835

Gene: INPP5D, SHIP, SHIP1
Protein: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q92835

Gene: INPP5D, SHIP, SHIP1 Protein: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: INPP5D, SHIP, SHIP1
Protein: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1