Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
2.3.1.48
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
histone acetyltransferase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| Biological Process | GO:0140861 | DNA repair-dependent chromatin remodeling |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0006302 | double-strand break repair |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0000132 | establishment of mitotic spindle orientation |
| Biological Process | GO:0043968 | histone H2A acetylation |
| Biological Process | GO:0043967 | histone H4 acetylation |
| Biological Process | GO:0016573 | histone acetylation |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0018393 | internal peptidyl-lysine acetylation |
| Biological Process | GO:1905691 | lipid droplet disassembly |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:2000042 | negative regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0032703 | negative regulation of interleukin-2 production |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0021915 | neural tube development |
| Biological Process | GO:0022008 | neurogenesis |
| Biological Process | GO:0006289 | nucleotide-excision repair |
| Biological Process | GO:0018394 | peptidyl-lysine acetylation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1902425 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0042753 | positive regulation of circadian rhythm |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0045089 | positive regulation of innate immune response |
| Biological Process | GO:0062033 | positive regulation of mitotic sister chromatid segregation |
| Biological Process | GO:0045663 | positive regulation of myoblast differentiation |
| Biological Process | GO:1901985 | positive regulation of protein acetylation |
| Biological Process | GO:0045591 | positive regulation of regulatory T cell differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010867 | positive regulation of triglyceride biosynthetic process |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000779 | regulation of double-strand break repair |
| Biological Process | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| Biological Process | GO:0010212 | response to ionizing radiation |
| Biological Process | GO:0035092 | sperm DNA condensation |
| Biological Process | GO:0007286 | spermatid development |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0010698 | acetyltransferase activator activity |
| Molecular Function | GO:0016407 | acetyltransferase activity |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0043998 | histone H2A acetyltransferase activity |
| Molecular Function | GO:0043999 | histone H2AK5 acetyltransferase activity |
| Molecular Function | GO:0010485 | histone H4 acetyltransferase activity |
| Molecular Function | GO:0046972 | histone H4K16 acetyltransferase activity |
| Molecular Function | GO:0004402 | histone acetyltransferase activity |
| Molecular Function | GO:0035034 | histone acetyltransferase regulator activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0106226 | peptide 2-hydroxyisobutyryltransferase activity |
| Molecular Function | GO:0140065 | peptide butyryltransferase activity |
| Molecular Function | GO:0140064 | peptide crotonyltransferase activity |
| Molecular Function | GO:0061733 | peptide-lysine-N-acetyltransferase activity |
| Molecular Function | GO:0019211 | phosphatase activator activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0140537 | transcription regulator activator activity |
| Cellular Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Cellular Component | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex |
| Cellular Component | GO:0000812 | Swr1 complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0097431 | mitotic spindle pole |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0005667 | transcription regulator complex |
| InterPro
|
InterPro name |
|---|---|
| IPR000953 | Chromo/chromo shadow domain |
| IPR002717 | Histone acetyltransferase domain, MYST-type |
| IPR016181 | Acyl-CoA N-acyltransferase |
| IPR016197 | Chromo-like domain superfamily |
| IPR025995 | RNA binding activity-knot of a chromodomain |
| IPR036388 | Winged helix-like DNA-binding domain superfamily |
| IPR040706 | MYST, zinc finger domain |
| Pfam
|
Pfam name |
|---|---|
| PF01853 | MOZ/SAS family |
| PF11717 | RNA binding activity-knot of a chromodomain |
| PF17772 | MYST family zinc finger domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-3214847 | HATs acetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | Internal node | R-HSA-73894 | DNA Repair |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | Internal node | R-HSA-73894 | DNA Repair |
| R-HSA-5693607 | Processing of DNA double-strand break ends | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-69473 | G2/M DNA damage checkpoint | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-9018519 | Estrogen-dependent gene expression | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Chromosome | ECO:0000269 | PubMed:25560918 |
| Chromosome | ECO:0000269 | PubMed:27153538 |
| Chromosome | ECO:0000269 | PubMed:29335245 |
| Chromosome | ECO:0000269 | PubMed:33076429 |
| Chromosome, centromere, kinetochore | ECO:0000269 | PubMed:26829474 |
| Cytoplasm | ECO:0000269 | PubMed:25301942 |
| Cytoplasm, cytoskeleton, spindle pole | ECO:0000269 | PubMed:34608293 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:11262386 |
| Nucleus | ECO:0000269 | PubMed:11262386 |
| Nucleus | ECO:0000269 | PubMed:11416127 |
| Nucleus | ECO:0000269 | PubMed:12551922 |
| Nucleus | ECO:0000269 | PubMed:17360565 |
| Nucleus | ECO:0000269 | PubMed:17704809 |
| Nucleus | ECO:0000269 | PubMed:17996965 |
| Nucleus | ECO:0000269 | PubMed:25301942 |
| Nucleus | ECO:0000269 | PubMed:33938178 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:16387653 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000028 | Cryptorchidism |
| HP:0000047 | Hypospadias |
| HP:0000076 | Vesicoureteral reflux |
| HP:0000085 | Horseshoe kidney |
| HP:0000154 | Wide mouth |
| HP:0000176 | Submucous cleft hard palate |
| HP:0000179 | Thick lower lip vermilion |
| HP:0000252 | Microcephaly |
| HP:0000303 | Mandibular prognathia |
| HP:0000311 | Round face |
| HP:0000369 | Low-set ears |
| HP:0000414 | Bulbous nose |
| HP:0000486 | Strabismus |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000540 | Hypermetropia |
| HP:0000733 | Abnormal repetitive mannerisms |
| HP:0001250 | Seizure |
| HP:0001263 | Global developmental delay |
| HP:0001272 | Cerebellar atrophy |
| HP:0001338 | Partial agenesis of the corpus callosum |
| HP:0001629 | Ventricular septal defect |
| HP:0002360 | Sleep disturbance |
| HP:0003577 | Congenital onset |
| HP:0005164 | Dysplastic pulmonary valve |
| HP:0005280 | Depressed nasal bridge |
| HP:0005338 | Sparse lateral eyebrow |
| HP:0006989 | Dysplastic corpus callosum |
| HP:0007018 | Attention deficit hyperactivity disorder |
| HP:0007874 | Almond-shaped palpebral fissure |
| HP:0010864 | Intellectual disability, severe |
| HP:0011003 | High myopia |
| HP:0011225 | Epiblepharon |
| HP:0012168 | Head-banging |
| HP:0012368 | Flat face |
| HP:0025161 | Frequent temper tantrums |
| HP:0032471 | Focal polymicrogyria |
| HP:0100333 | Unilateral cleft lip |
| HP:0100334 | Unilateral cleft palate |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells type I | High | Approved |
| lung | alveolar cells type II | High | Approved |
| lung | endothelial cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| ovary | follicle cells | High | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities | MONDO:0030852 | G00 | chapter6, Diseases of the nervous system | OMIM:619103 | |
| neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities | MONDO:0030852 | G98 | chapter6, Diseases of the nervous system | OMIM:619103 |