Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.5.1.48
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
acetylspermidine deacetylase
3.5.1.62
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
acetylputrescine deacetylase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0016575 | histone deacetylation |
| Biological Process | GO:0035825 | homologous recombination |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034983 | peptidyl-lysine deacetylation |
| Biological Process | GO:0106047 | polyamine deacetylation |
| Biological Process | GO:0032425 | positive regulation of mismatch repair |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0106048 | spermidine deacetylation |
| Molecular Function | GO:0047609 | acetylputrescine deacetylase activity |
| Molecular Function | GO:0047611 | acetylspermidine deacetylase activity |
| Molecular Function | GO:0019213 | deacetylase activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0033558 | protein lysine deacetylase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-3214815 | HDACs deacetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-350054 | Notch-HLH transcription pathway | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:11677242 |
| Cytoplasm | ECO:0000269 | PubMed:11726666 |
| Cytoplasm | ECO:0000269 | PubMed:11739383 |
| Cytoplasm | ECO:0000269 | PubMed:11861901 |
| Cytoplasm | ECO:0000269 | PubMed:23801752 |
| Nucleus | ECO:0000269 | PubMed:11677242 |
| Nucleus | ECO:0000269 | PubMed:11726666 |
| Nucleus | ECO:0000269 | PubMed:11739383 |
| Nucleus | ECO:0000269 | PubMed:11861901 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | Medium | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| bone marrow | hematopoietic cells | Medium | Supported |
| breast | adipocytes | Medium | Supported |
| breast | glandular cells | Medium | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | High | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebellum | cells in granular layer | High | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | Low | Supported |
| cerebral cortex | glial cells | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cerebral cortex | neuropil | Medium | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | Medium | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | High | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | cells in tubules | High | Supported |
| liver | cholangiocytes | Medium | Supported |
| liver | hepatocytes | High | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | alveolar cells type II | Medium | Supported |
| lung | endothelial cells | Low | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | High | Supported |
| ovary | follicle cells | Medium | Supported |
| ovary | ovarian stroma cells | High | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | Medium | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | High | Supported |
| placenta | trophoblastic cells | High | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | Medium | Supported |
| skin 1 | Langerhans | Medium | Supported |
| skin 1 | fibroblasts | High | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | chondrocytes | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| soft tissue 2 | peripheral nerve | Medium | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | Medium | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | pachytene spermatocytes | High | Supported |
| testis | preleptotene spermatocytes | Low | Supported |
| testis | round or early spermatids | High | Supported |
| testis | sertoli cells | Medium | Supported |
| testis | spermatogonia cells | Medium | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | High | Supported |
| tonsil | non-germinal center cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|