Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0043984 | histone H4-K16 acetylation |
| Biological Process | GO:0043981 | histone H4-K5 acetylation |
| Biological Process | GO:0043982 | histone H4-K8 acetylation |
| Biological Process | GO:0051974 | negative regulation of telomerase activity |
| Biological Process | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0051571 | positive regulation of histone H3-K4 methylation |
| Biological Process | GO:1904751 | positive regulation of protein localization to nucleolus |
| Biological Process | GO:1904507 | positive regulation of telomere maintenance in response to DNA damage |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0060382 | regulation of DNA strand elongation |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0033044 | regulation of chromosome organization |
| Biological Process | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0000723 | telomere maintenance |
| Molecular Function | GO:0002151 | G-quadruplex RNA binding |
| Molecular Function | GO:0034046 | poly(G) binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:0010521 | telomerase inhibitor activity |
| Cellular Component | GO:0031011 | Ino80 complex |
| Cellular Component | GO:0071339 | MLL1 complex |
| Cellular Component | GO:0044545 | NSL complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0000123 | histone acetyltransferase complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005844 | polysome |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-3214847 | HATs acetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-5689603 | UCH proteinases | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:16571602 |
| Nucleus | ECO:0000269 | PubMed:15044100 |
| Nucleus | ECO:0000269 | PubMed:16571602 |
| Nucleus | ECO:0000269 | PubMed:18922472 |
| Nucleus | ECO:0000269 | PubMed:20018852 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:16571602 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:9654073 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | High | Supported |
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | Medium | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | adipocytes | High | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | High | Supported |
| bronchus | basal cells | High | Supported |
| bronchus | ciliated cells (cell body) | Medium | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | glial cells | High | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | Medium | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | ciliated cells (cell body) | Medium | Supported |
| fallopian tube | non-ciliated cells | Medium | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | High | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Medium | Supported |
| liver | hepatocytes | Medium | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | alveolar cells type II | High | Supported |
| lung | endothelial cells | High | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | basal cells | High | Supported |
| nasopharynx | ciliated cells (cell body) | High | Supported |
| oral mucosa | squamous epithelial cells | High | Supported |
| ovary | follicle cells | High | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | High | Supported |
| placenta | trophoblastic cells | High | Supported |
| prostate | glandular cells | High | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | Medium | Supported |
| skin 1 | Langerhans | High | Supported |
| skin 1 | fibroblasts | High | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | High | Supported |
| skin 2 | epidermal cells | High | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | chondrocytes | High | Supported |
| soft tissue 1 | fibroblasts | High | Supported |
| soft tissue 2 | fibroblasts | High | Supported |
| soft tissue 2 | peripheral nerve | Low | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | Medium | Supported |
| stomach 1 | glandular cells | Medium | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | pachytene spermatocytes | High | Supported |
| testis | peritubular cells | Low | Supported |
| testis | preleptotene spermatocytes | High | Supported |
| testis | round or early spermatids | High | Supported |
| testis | sertoli cells | High | Supported |
| testis | spermatogonia cells | High | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Medium | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|