MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.14.14.-	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor;
4.2.1.152	Lyases; Carbon-oxygen lyases; Hydro-lyases; hydroperoxy icosatetraenoate dehydratase
5.3.99.5	Isomerases; Intramolecular oxidoreductases; Other intramolecular oxidoreductases; thromboxane-A synthase

GO ontology	GO term	GO description
Biological Process	GO:0019373	epoxygenase P450 pathway
Biological Process	GO:0006690	icosanoid metabolic process
Biological Process	GO:0006693	prostaglandin metabolic process
Biological Process	GO:0042573	retinoic acid metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0036134	12-hydroxyheptadecatrienoic acid synthase activity
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0016836	hydro-lyase activity
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0004497	monooxygenase activity
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity
Molecular Function	GO:0004796	thromboxane-A synthase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0043231	intracellular membrane-bounded organelle

InterPro	InterPro name
IPR001128	Cytochrome P450
IPR002401	Cytochrome P450, E-class, group I
IPR008067	Cytochrome P450, E-class, group I, CYP2A-like
IPR017972	Cytochrome P450, conserved site
IPR036396	Cytochrome P450 superfamily

Pfam	Pfam name
PF00067	Cytochrome P450

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-211958	Miscellaneous substrates	Leaf	R-HSA-1430728	Metabolism
R-HSA-211981	Xenobiotics	Internal node	R-HSA-1430728	Metabolism
R-HSA-211999	CYP2E1 reactions	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Endoplasmic reticulum membrane	ECO:0000269	PubMed:11181079
Microsome membrane	ECO:0000269	PubMed:11181079

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Low	Approved
bone marrow	hematopoietic cells	Low	Approved
breast	glandular cells	Medium	Approved
colon	glandular cells	Low	Approved
duodenum	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
gallbladder	glandular cells	Low	Approved
heart muscle	cardiomyocytes	Low	Approved
kidney	cells in tubules	Low	Approved
liver	hepatocytes	Low	Approved
lung	macrophages	Medium	Approved
nasopharynx	basal cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Low	Approved
skeletal muscle	myocytes	Medium	Approved
small intestine	glandular cells	High	Approved
spleen	cells in red pulp	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Low	Approved