MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.2.27	Transferases; Acyltransferases; Aminoacyltransferases; RING-type E3 ubiquitin transferase

PDB	Resolution (Å)	PDB name
2H0D	2.5	Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex
3GS2	1.699	Ring1B C-terminal domain/Cbx7 Cbox Complex
3H8H	2.0	Structure of the C-terminal domain of human RNF2/RING1B;
3IXS	1.7	Ring1B C-terminal domain/RYBP C-terminal domain Complex
3RPG	2.6485	Bmi1/Ring1b-UbcH5c complex structure
4R8P	3.2846	Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle
4S3O	2.0	PCGF5-RING1B-UbcH5c complex
6WI7	1.702	RING1B-BMI1 fusion in closed conformation
6WI8	3.092	Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure
7ND1		First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain

GO ontology	GO term	GO description
Biological Process	GO:0009948	anterior/posterior axis specification
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0040029	epigenetic regulation of gene expression
Biological Process	GO:0001702	gastrulation with mouth forming second
Biological Process	GO:0010467	gene expression
Biological Process	GO:0007281	germ cell development
Biological Process	GO:0035518	histone H2A monoubiquitination
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Molecular Function	GO:0071535	RING-like zinc finger domain binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0140862	histone H2AK119 ubiquitin ligase activity
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0071339	MLL1 complex
Cellular Component	GO:0035102	PRC1 complex
Cellular Component	GO:0031519	PcG protein complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0001739	sex chromatin
Cellular Component	GO:0000151	ubiquitin ligase complex

InterPro	InterPro name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR017907	Zinc finger, RING-type, conserved site
IPR032443	RAWUL domain
IPR037937	E3 ubiquitin-protein ligase RING2, RAWUL domain
IPR043540	E3 ubiquitin-protein ligase RING1/RING2

Pfam	Pfam name
PF13923	Zinc finger, C3HC4 type (RING finger)
PF16207	RAWUL domain RING finger- and WD40-associated ubiquitin-like

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2559580	Oxidative Stress Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3899300	SUMOylation of transcription cofactors	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4551638	SUMOylation of chromatin organization proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4570464	SUMOylation of RNA binding proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4655427	SUMOylation of DNA methylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8943724	Regulation of PTEN gene transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8953750	Transcriptional Regulation by E2F6	Leaf	R-HSA-74160	Gene expression (Transcription)

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000154	Wide mouth
HP:0000160	Narrow mouth
HP:0000316	Hypertelorism
HP:0000322	Short philtrum
HP:0000377	Abnormal pinna morphology
HP:0000403	Recurrent otitis media
HP:0000445	Wide nose
HP:0000463	Anteverted nares
HP:0000483	Astigmatism
HP:0000486	Strabismus
HP:0000490	Deeply set eye
HP:0000527	Long eyelashes
HP:0000577	Exotropia
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001347	Hyperreflexia
HP:0001508	Failure to thrive
HP:0001511	Intrauterine growth retardation
HP:0001537	Umbilical hernia
HP:0001562	Oligohydramnios
HP:0001566	Widely-spaced maxillary central incisors
HP:0001773	Short foot
HP:0002553	Highly arched eyebrow
HP:0005180	Tricuspid regurgitation
HP:0005280	Depressed nasal bridge
HP:0007651	Ectropion of lower eyelids
HP:0007874	Almond-shaped palpebral fissure
HP:0008872	Feeding difficulties in infancy
HP:0010864	Intellectual disability, severe
HP:0011344	Severe global developmental delay
HP:0011451	Primary microcephaly
HP:0011461	Fetal onset
HP:0012471	Thick vermilion border
HP:0200055	Small hand