MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.2.-	Hydrolases; Acting on ester bonds; Thioester hydrolases;
3.5.1.-	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides;
3.5.1.124	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides; protein deglycase

Structure

PDB	Resolution (Å)	PDB name
1J42	2.5	Crystal Structure of Human DJ-1
1P5F	1.1	Crystal Structure of Human DJ-1
1PDV	1.8	Crystal structure of human DJ-1, P 31 2 1 space group
1PDW	2.2	Crystal structure of human DJ-1, P 1 21 1 space group
1PE0	1.7	Crystal structure of the K130R mutant of human DJ-1
1Q2U	1.6	Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
1SOA	1.2	Human DJ-1 with sulfinic acid
1UCF	1.95	The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease
2OR3	1.2	Pre-oxidation Complex of Human DJ-1
2R1T	1.7	dopamine quinone conjugation to DJ-1
2R1U	1.5	DJ-1 activation by catechol quinone modification
2R1V	1.7	Norepinephrine quinone conjugation to DJ-1
2RK3	1.05	Structure of A104T DJ-1
2RK4	1.15	Structure of M26I DJ-1
2RK6	1.15	Structure of E163K DJ-1
3B36	1.5	Structure of M26L DJ-1
3B38	1.85	Structure of A104V DJ-1
3B3A	1.5	Structure of E163K/R145E DJ-1
3BWE	2.4	Crystal structure of aggregated form of DJ1
3CY6	1.35	Crystal Structure of E18Q DJ-1
3CYF	1.6	Crystal Structure of E18N DJ-1
3CZ9	1.15	Crystal Structure of E18L DJ-1
3CZA	1.2	Crystal Structure of E18D DJ-1
3EZG	1.15	Crystal structure of E18Q DJ-1 with oxidized C106
3F71	1.2	Crystal structure of E18D DJ-1 with oxidized C106
3SF8	1.56	Structural insights into thiol stabilization of DJ-1
4BTE	1.38	DJ-1 Cu(I) complex
4MNT	1.584	Crystal structure of human DJ-1 in complex with Cu
4MTC	1.47	Crystal structure of human C53A DJ-1
4N0M	1.95	Crystal structure of human C53A DJ-1 in complex with Cu
4N12	1.478	Crystal structure of human E18D DJ-1 in complex with Cu
4OGF	1.6	Crystal Structure of Human DJ-1 with glyoxylate as substrate analog
4OQ4	1.49	Crystal Structure of E18A Human DJ-1
4P2G	1.35	Crystal structure of DJ-1 in sulfinic acid form (aged crystal)
4P34	1.55	Crystal structure of DJ-1 in sulfenic acid form (fresh crystal)
4P35	1.75	Crystal structure of DJ-1 with Zinc(II) bound (crystal I)
4P36	1.182	Crystal structure of DJ-1 With Zn(II) bound (crystal 2)
4RKW	1.5	Crystal structure of DJ-1
4RKY	1.5	Crystal structure of DJ-1 isoform X1
4S0Z	1.45	Crystal structure of M26V human DJ-1
4ZGG	1.23	Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution
5IP5	1.66	Human DJ-1 complexed with Na-K-tartrate
5SY6	1.15	Atomic resolution structure of human DJ-1, DTT bound
5SY9	1.1	Atomic resolution structure of E15Q mutant human DJ-1
5SYA	1.1	Atomic resolution structure of D24N mutant human DJ-1
6AF5	1.65	DJ-1 after backsoaking
6AF7	1.3	DJ-1 C106S unbound
6AF9	1.39	DJ-1 with isatin bound (high concentration)
6AFA	1.65	DJ-1 with isatin (low concentration)
6AFB	1.6	DJ-1 C106S incubated with isatin
6AFC	1.45	DJ-1 with compound 4
6AFD	1.48	DJ-1 with compound 6
6AFE	1.5	DJ-1 with compound 7
6AFF	1.6	DJ-1 with compound 8
6AFG	1.5	DJ-1 with compound 9
6AFH	1.65	DJ-1 with compound 10
6AFI	1.65	DJ-1 with compound 11
6AFJ	1.48	DJ-1 with compound 13
6AFL	1.6	DJ-1 with compound 15
6E5Z	1.35	Crystal structure of human DJ-1 with a natural modification on Cys-106
6M8Z	1.83	Crystal structure of human DJ-1 without a modification on Cys-106
7C62	2.027	The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Biortus
7PA2	1.21	PARK7 with inhibitor 8RK64
7PA3	1.42	PARK7 with covalent inhibitor JYQ-88

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0007265	Ras protein signal transduction
Biological Process	GO:0032148	activation of protein kinase B activity
Biological Process	GO:0008344	adult locomotory behavior
Biological Process	GO:0006914	autophagy
Biological Process	GO:0110095	cellular detoxification of aldehyde
Biological Process	GO:0140041	cellular detoxification of methylglyoxal
Biological Process	GO:0036471	cellular response to glyoxal
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0070994	detection of oxidative stress
Biological Process	GO:0010273	detoxification of copper ion
Biological Process	GO:0061691	detoxification of hydrogen peroxide
Biological Process	GO:0050787	detoxification of mercury ion
Biological Process	GO:0051583	dopamine uptake involved in synaptic transmission
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0036531	glutathione deglycation
Biological Process	GO:0046295	glycolate biosynthetic process
Biological Process	GO:1903189	glyoxal metabolic process
Biological Process	GO:0106044	guanine deglycation
Biological Process	GO:0106046	guanine deglycation, glyoxal removal
Biological Process	GO:0106045	guanine deglycation, methylglyoxal removal
Biological Process	GO:0042743	hydrogen peroxide metabolic process
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0030073	insulin secretion
Biological Process	GO:0019249	lactate biosynthetic process
Biological Process	GO:0051899	membrane depolarization
Biological Process	GO:0060081	membrane hyperpolarization
Biological Process	GO:0061727	methylglyoxal catabolic process to lactate
Biological Process	GO:0009438	methylglyoxal metabolic process
Biological Process	GO:0007005	mitochondrion organization
Biological Process	GO:1903122	negative regulation of TRAIL-activated apoptotic signaling pathway
Biological Process	GO:0060548	negative regulation of cell death
Biological Process	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process	GO:1903073	negative regulation of death-inducing signaling complex assembly
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death
Biological Process	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:1901215	negative regulation of neuron death
Biological Process	GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
Biological Process	GO:1903202	negative regulation of oxidative stress-induced cell death
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:1903094	negative regulation of protein K48-linked deubiquitination
Biological Process	GO:1901984	negative regulation of protein acetylation
Biological Process	GO:0032091	negative regulation of protein binding
Biological Process	GO:0046826	negative regulation of protein export from nucleus
Biological Process	GO:0006469	negative regulation of protein kinase activity
Biological Process	GO:0001933	negative regulation of protein phosphorylation
Biological Process	GO:0033234	negative regulation of protein sumoylation
Biological Process	GO:0031397	negative regulation of protein ubiquitination
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity
Biological Process	GO:2000157	negative regulation of ubiquitin-specific protease activity
Biological Process	GO:0036527	peptidyl-arginine deglycation
Biological Process	GO:0036526	peptidyl-cysteine deglycation
Biological Process	GO:0036528	peptidyl-lysine deglycation
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity
Biological Process	GO:1903197	positive regulation of L-dopa biosynthetic process
Biological Process	GO:1903200	positive regulation of L-dopa decarboxylase activity
Biological Process	GO:0033864	positive regulation of NAD(P)H oxidase activity
Biological Process	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus
Biological Process	GO:2000825	positive regulation of androgen receptor activity
Biological Process	GO:1903599	positive regulation of autophagy of mitochondrion
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0051897	positive regulation of protein kinase B signaling
Biological Process	GO:1900182	positive regulation of protein localization to nucleus
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly
Biological Process	GO:1903168	positive regulation of pyrroline-5-carboxylate reductase activity
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process
Biological Process	GO:1901671	positive regulation of superoxide dismutase activity
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding
Biological Process	GO:1903178	positive regulation of tyrosine 3-monooxygenase activity
Biological Process	GO:0036529	protein deglycation, glyoxal removal
Biological Process	GO:0036530	protein deglycation, methylglyoxal removal
Biological Process	GO:0006517	protein deglycosylation
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0060765	regulation of androgen receptor signaling pathway
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0051881	regulation of mitochondrial membrane potential
Biological Process	GO:0043523	regulation of neuron apoptotic process
Biological Process	GO:1902903	regulation of supramolecular fiber organization
Biological Process	GO:0006979	response to oxidative stress
Biological Process	GO:0007338	single fertilization
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0036478	L-dopa decarboxylase activator activity
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:1903135	cupric ion binding
Molecular Function	GO:1903136	cuprous ion binding
Molecular Function	GO:0019955	cytokine binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:1990422	glyoxalase (glycolic acid-forming) activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0045340	mercury ion binding
Molecular Function	GO:0050681	nuclear androgen receptor binding
Molecular Function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor
Molecular Function	GO:0019826	oxygen sensor activity
Molecular Function	GO:0008233	peptidase activity
Molecular Function	GO:0051920	peroxiredoxin activity
Molecular Function	GO:0036524	protein deglycase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0097110	scaffold protein binding
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0044388	small protein activating enzyme binding
Molecular Function	GO:0016532	superoxide dismutase copper chaperone activity
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0036470	tyrosine 3-monooxygenase activator activity
Molecular Function	GO:0044390	ubiquitin-like protein conjugating enzyme binding
Molecular Function	GO:1990381	ubiquitin-specific protease binding
Cellular Component	GO:0016605	PML body
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0030424	axon
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse

InterPro / Pfam

InterPro	InterPro name
IPR002818	DJ-1/PfpI
IPR006287	Protein/nucleic acid deglycase DJ-1
IPR029062	Class I glutamine amidotransferase-like

Pfam	Pfam name
PF01965	DJ-1/PfpI family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-3899300	SUMOylation of transcription cofactors	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9613829	Chaperone Mediated Autophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-9615710	Late endosomal microautophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-9646399	Aggrephagy	Leaf	R-HSA-9612973	Autophagy

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000250
Cytoplasm	ECO:0000269	PubMed:12851414
Cytoplasm	ECO:0000269	PubMed:14579415
Cytoplasm	ECO:0000269	PubMed:15976810
Cytoplasm	ECO:0000269	PubMed:19229105
Cytoplasm	ECO:0000269	PubMed:28596309
Endoplasmic reticulum	ECO:0000269	PubMed:31536960
Membrane raft	ECO:0000250
Mitochondrion	ECO:0000269	PubMed:15181200
Mitochondrion	ECO:0000269	PubMed:18711745
Mitochondrion	ECO:0000269	PubMed:19229105
Mitochondrion	ECO:0000269	PubMed:31536960
Nucleus	ECO:0000269	PubMed:12851414
Nucleus	ECO:0000269	PubMed:14579415
Nucleus	ECO:0000269	PubMed:15976810
Nucleus	ECO:0000269	PubMed:16390825
Nucleus	ECO:0000269	PubMed:28596309

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000551	Color vision defect
HP:0000643	Blepharospasm
HP:0000651	Diplopia
HP:0000713	Agitation
HP:0000716	Depression
HP:0000725	Psychotic episodes
HP:0000726	Dementia
HP:0000727	Frontal lobe dementia
HP:0000735	Impaired social interactions
HP:0000736	Short attention span
HP:0000738	Hallucinations
HP:0000739	Anxiety
HP:0000741	Apathy
HP:0001257	Spasticity
HP:0001332	Dystonia
HP:0001337	Tremor
HP:0001347	Hyperreflexia
HP:0001348	Brisk reflexes
HP:0002014	Diarrhea
HP:0002018	Nausea
HP:0002019	Constipation
HP:0002063	Rigidity
HP:0002067	Bradykinesia
HP:0002141	Gait imbalance
HP:0002172	Postural instability
HP:0002174	Postural tremor
HP:0002322	Resting tremor
HP:0002548	Parkinsonism with favorable response to dopaminergic medication
HP:0002578	Gastroparesis
HP:0003394	Muscle spasm
HP:0003581	Adult onset
HP:0003677	Slowly progressive
HP:0004409	Hyposmia
HP:0012332	Abnormal autonomic nervous system physiology
HP:0012452	Restless legs
HP:0025269	Panic attack
HP:0030014	Female sexual dysfunction
HP:0031959	Leg dystonia
HP:0040307	Male sexual dysfunction
HP:0100543	Cognitive impairment
HP:0100660	Dyskinesia
HP:0100710	Impulsivity
HP:0100785	Insomnia

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Supported
adrenal gland	glandular cells	High	Supported
appendix	endocrine cells	Low	Supported
appendix	enterocytes	Low	Supported
appendix	non-germinal center cells	Medium	Supported
bone marrow	hematopoietic cells	Medium	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	Medium	Supported
caudate	glial cells	Medium	Supported
cerebellum	Purkinje cells	Medium	Supported
cerebellum	cells in granular layer	Medium	Supported
cerebellum	cells in molecular layer	Medium	Supported
cerebral cortex	endothelial cells	Low	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuronal cells	Medium	Supported
cerebral cortex	neuropil	Medium	Supported
cervix	glandular cells	Medium	Supported
colon	endocrine cells	Medium	Supported
colon	endothelial cells	Medium	Supported
colon	enterocytes	Medium	Supported
colon	fibroblasts	Medium	Supported
colon	mucosal lymphoid cells	Medium	Supported
colon	peripheral nerve/ganglion	Low	Supported
duodenum	endocrine cells	Medium	Supported
duodenum	enterocytes	Low	Supported
duodenum	glands of Brunner	High	Supported
duodenum	goblet cells	Low	Supported
duodenum	paneth cells	High	Supported
endometrium 1	cells in endometrial stroma	Medium	Supported
endometrium 1	glandular cells	Medium	Supported
endometrium 2	cells in endometrial stroma	Medium	Supported
endometrium 2	glandular cells	Medium	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	Medium	Supported
fallopian tube	glandular cells	High	Supported
heart muscle	cardiomyocytes	Low	Supported
hippocampus	glial cells	High	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	Medium	Supported
kidney	cells in tubules	Medium	Supported
liver	cholangiocytes	Medium	Supported
liver	hepatocytes	Medium	Supported
lung	alveolar cells type I	High	Supported
lung	alveolar cells type II	High	Supported
lung	endothelial cells	Medium	Supported
lung	macrophages	Medium	Supported
lymph node	germinal center cells	Medium	Supported
lymph node	non-germinal center cells	Medium	Supported
nasopharynx	respiratory epithelial cells	Medium	Supported
oral mucosa	squamous epithelial cells	Medium	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	High	Supported
pancreas	pancreatic endocrine cells	High	Supported
parathyroid gland	glandular cells	High	Supported
placenta	trophoblastic cells	Medium	Supported
prostate	glandular cells	High	Supported
rectum	endocrine cells	Medium	Supported
rectum	endothelial cells	Medium	Supported
rectum	enterocytes	Medium	Supported
rectum	fibroblasts	Medium	Supported
rectum	mucosal lymphoid cells	Medium	Supported
rectum	peripheral nerve/ganglion	Low	Supported
salivary gland	glandular cells	Medium	Supported
seminal vesicle	glandular cells	High	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in basal layer	Low	Supported
skin 1	endothelial cells	Low	Supported
skin 1	fibrohistiocytic cells	Low	Supported
skin 1	lymphocytes	Low	Supported
skin 2	cells in basal layer	Low	Supported
skin 2	endothelial cells	Low	Supported
skin 2	fibrohistiocytic cells	Medium	Supported
skin 2	lymphocytes	Low	Supported
small intestine	endocrine cells	Medium	Supported
small intestine	enterocytes	Low	Supported
smooth muscle	smooth muscle cells	Low	Supported
soft tissue 1	chondrocytes	High	Supported
soft tissue 1	fibroblasts	Medium	Supported
soft tissue 1	peripheral nerve	Low	Supported
soft tissue 2	fibroblasts	Medium	Supported
soft tissue 2	peripheral nerve	Medium	Supported
spleen	cells in red pulp	Medium	Supported
spleen	cells in white pulp	Medium	Supported
stomach 1	glandular cells	Medium	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	Medium	Supported
testis	round or early spermatids	Low	Supported
testis	spermatogonia cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	Medium	Supported
tonsil	non-germinal center cells	Medium	Supported
tonsil	squamous epithelial cells	Medium	Supported
urinary bladder	urothelial cells	Medium	Supported
vagina	squamous epithelial cells	Low	Supported

Summary of Q99497

Gene: PARK7
Protein: Parkinson disease protein 7

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q99497

Gene: PARK7 Protein: Parkinson disease protein 7

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PARK7
Protein: Parkinson disease protein 7