Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1KPP | Structure of the Tsg101 UEV domain | |
1KPQ | Structure of the Tsg101 UEV domain | |
1M4P | Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP late domain peptide, DYANA Ensemble | |
1M4Q | STRUCTURE OF THE TSG101 UEV DOMAIN IN COMPLEX WITH A HIV-1 PTAP LATE DOMAIN PEPTIDE, CNS ENSEMBLE | |
1S1Q | 2.0 | TSG101(UEV) domain in complex with Ubiquitin |
2F0R | 2.26 | Crystallographic structure of human Tsg101 UEV domain |
3IV1 | 2.5 | Coiled-coil domain of tumor susceptibility gene 101 |
3OBQ | 1.4 | Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide |
3OBS | 1.5 | Crystal structure of Tsg101 UEV domain |
3OBU | 1.6 | Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP peptide |
3OBX | 1.6 | Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide |
3P9G | 1.8 | Crystal structure of the TSG101 UEV domain in complex with FA459 peptide |
3P9H | 1.8 | Crystal structure of the TSG101 UEV domain in complex with FA258 peptide |
4EJE | 2.2 | Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide |
4YC1 | 2.0 | Structure of the human TSG101-UEV domain in the P321 space group |
4ZNY | 2.4 | Structure of the human TSG101-UEV Domain in complex with the PTAP motif of the p19 gag protein of the Human T-cell Leukemia type I virus |
5VKG | Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole | |
6UD0 | Solution-state NMR structural ensemble of human Tsg101 UEV in complex with K63-linked diubiquitin | |
6VME | 2.19 | Human ESCRT-I heterotetramer headpiece |
7NLC | 1.398 | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide |
7ZLX | 2.25 | Crystal Structure of the TSG101-UEV domain:space group P21 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0097352 | autophagosome maturation |
Biological Process | GO:0007049 | cell cycle |
Biological Process | GO:0051301 | cell division |
Biological Process | GO:0008333 | endosome to lysosome transport |
Biological Process | GO:1990182 | exosomal secretion |
Biological Process | GO:0006858 | extracellular transport |
Biological Process | GO:0030216 | keratinocyte differentiation |
Biological Process | GO:0016236 | macroautophagy |
Biological Process | GO:0090148 | membrane fission |
Biological Process | GO:0036258 | multivesicular body assembly |
Biological Process | GO:0008285 | negative regulation of cell population proliferation |
Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
Biological Process | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Biological Process | GO:1903543 | positive regulation of exosomal secretion |
Biological Process | GO:2000397 | positive regulation of ubiquitin-dependent endocytosis |
Biological Process | GO:1903774 | positive regulation of viral budding via host ESCRT complex |
Biological Process | GO:0006513 | protein monoubiquitination |
Biological Process | GO:0043328 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Biological Process | GO:0043405 | regulation of MAP kinase activity |
Biological Process | GO:0051726 | regulation of cell cycle |
Biological Process | GO:0001558 | regulation of cell growth |
Biological Process | GO:1903551 | regulation of extracellular exosome assembly |
Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Biological Process | GO:0046755 | viral budding |
Biological Process | GO:0039702 | viral budding via host ESCRT complex |
Biological Process | GO:0019076 | viral release from host cell |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0048306 | calcium-dependent protein binding |
Molecular Function | GO:0030374 | nuclear receptor coactivator activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0044877 | protein-containing complex binding |
Molecular Function | GO:0003714 | transcription corepressor activity |
Molecular Function | GO:0043130 | ubiquitin binding |
Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
Molecular Function | GO:0046790 | virion binding |
Cellular Component | GO:0000813 | ESCRT I complex |
Cellular Component | GO:0090543 | Flemming body |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005769 | early endosome |
Cellular Component | GO:0031901 | early endosome membrane |
Cellular Component | GO:0005768 | endosome |
Cellular Component | GO:0010008 | endosome membrane |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005770 | late endosome |
Cellular Component | GO:0031902 | late endosome membrane |
Cellular Component | GO:0005815 | microtubule organizing center |
Cellular Component | GO:0005771 | multivesicular body |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005886 | plasma membrane |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-162588 | Budding and maturation of HIV virion | Leaf | R-HSA-1643685 | Disease |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | Leaf | R-HSA-1643685 | Disease |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
R-HSA-9610379 | HCMV Late Events | Leaf | R-HSA-1643685 | Disease |
R-HSA-9615710 | Late endosomal microautophagy | Leaf | R-HSA-9612973 | Autophagy |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:17853893 |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:17853893 |
Early endosome membrane | ECO:0000269 | PubMed:23166352 |
Late endosome membrane | ECO:0000269 | PubMed:11916981 |
Late endosome membrane | ECO:0000269 | PubMed:17229889 |
Midbody, Midbody ring | ECO:0000269 | PubMed:17556548 |
Midbody, Midbody ring | ECO:0000269 | PubMed:17853893 |
Nucleus | ECO:0000269 | PubMed:17229889 |