Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.1.-
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
3.6.1.22
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
NAD+ diphosphatase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 6SCX | 2.92 | Crystal structure of the catalytic domain of human NUDT12 in complex with 7-methyl-guanosine-5'-triphosphate |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway |
| Biological Process | GO:0019677 | NAD catabolic process |
| Biological Process | GO:0110155 | NAD-cap decapping |
| Biological Process | GO:0006734 | NADH metabolic process |
| Biological Process | GO:0006742 | NADP catabolic process |
| Biological Process | GO:0032922 | circadian regulation of gene expression |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0110156 | methylguanosine-cap decapping |
| Molecular Function | GO:0000210 | NAD+ diphosphatase activity |
| Molecular Function | GO:0035529 | NADH pyrophosphatase activity |
| Molecular Function | GO:0110153 | RNA NAD-cap (NMN-forming) hydrolase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:1990174 | phosphodiesterase decapping endonuclease activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| InterPro
|
InterPro name |
|---|---|
| IPR000086 | NUDIX hydrolase domain |
| IPR002110 | Ankyrin repeat |
| IPR015375 | NADH pyrophosphatase-like, N-terminal |
| IPR015376 | Zinc ribbon, NADH pyrophosphatase |
| IPR015797 | NUDIX hydrolase-like domain superfamily |
| IPR020084 | NUDIX hydrolase, conserved site |
| IPR036770 | Ankyrin repeat-containing domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00293 | NUDIX domain |
| PF09296 | NADH pyrophosphatase-like rudimentary NUDIX domain |
| PF09297 | NADH pyrophosphatase zinc ribbon domain |
| PF12796 | Ankyrin repeats (3 copies) |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-197264 | Nicotinamide salvaging | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:12790796 |
| Cytoplasmic granule | ECO:0000269 | PubMed:31875550 |
| Peroxisome | ECO:0000269 | PubMed:12790796 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | High | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| bone marrow | hematopoietic cells | Low | Supported |
| breast | adipocytes | Low | Supported |
| breast | glandular cells | Medium | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebellum | cells in molecular layer | Low | Supported |
| cerebral cortex | glial cells | Medium | Supported |
| cerebral cortex | neuronal cells | Medium | Supported |
| cerebral cortex | neuropil | Medium | Supported |
| cervix | glandular cells | Medium | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Low | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | Medium | Supported |
| esophagus | squamous epithelial cells | Medium | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | High | Supported |
| kidney | cells in tubules | High | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells type II | High | Supported |
| lung | endothelial cells | High | Supported |
| lung | macrophages | High | Supported |
| lymph node | germinal center cells | Low | Supported |
| nasopharynx | respiratory epithelial cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | Medium | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | High | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skeletal muscle | myocytes | Medium | Supported |
| skin 1 | Langerhans | Medium | Supported |
| skin 1 | fibroblasts | High | Supported |
| skin 1 | melanocytes | High | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | chondrocytes | High | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 1 | peripheral nerve | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| soft tissue 2 | peripheral nerve | Medium | Supported |
| spleen | cells in red pulp | Medium | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | High | Supported |
| testis | sertoli cells | High | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|