Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
5.3.1.23
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds;
S-methyl-5-thioribose-1-phosphate isomerase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019284 | L-methionine salvage from S-adenosylmethionine |
| Biological Process | GO:0019509 | L-methionine salvage from methylthioadenosine |
| Molecular Function | GO:0046523 | S-methyl-5-thioribose-1-phosphate isomerase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005654 | nucleoplasm |
| InterPro
|
InterPro name |
|---|---|
| IPR000649 | Initiation factor 2B-related |
| IPR005251 | Methylthioribose-1-phosphate isomerase |
| IPR011559 | Initiation factor 2B alpha/beta/delta |
| IPR027363 | Methylthioribose-1-phosphate isomerase, N-terminal |
| IPR037171 | NagB/RpiA transferase-like |
| IPR042529 | Initiation factor 2B-like, C-terminal |
| Pfam
|
Pfam name |
|---|---|
| PF01008 | Initiation factor 2 subunit family |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1237112 | Methionine salvage pathway | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell projection | ECO:0000269 | PubMed:19620624 |
| Cytoplasm | ECO:0000255 | |
| Cytoplasm | ECO:0000269 | PubMed:19620624 |
| Nucleus | ECO:0000255 | |
| Nucleus | ECO:0000269 | PubMed:19620624 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | High | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells type II | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | sertoli cells | Low | Approved |
| testis | spermatogonia cells | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|