MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.7.108	Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases; protein adenylyltransferase
3.1.4.-	Hydrolases; Acting on ester bonds; Phosphoric-diester hydrolases;

Structure

PDB	Resolution (Å)	PDB name
4U04	2.48	Structure of a eukaryotic fic domain containing protein
4U07	2.64	ATP bound to eukaryotic FIC domain containing protein
4U0S	2.49	Structure of Eukaryotic fic domain containing protein with ADP
4U0U	2.98	Wild type eukaryotic fic domain containing protein with ADP
4U0Z	2.95	Eukaryotic Fic Domain containing protein with bound APCPP
6I7G	2.7	Crystal structure of dimeric wild type FICD complexed with ATP
6I7H	2.25	Crystal structure of dimeric FICD mutant K256S
6I7I	2.33	Crystal structure of dimeric FICD mutant K256A complexed with MgATP
6I7J	2.65	Crystal structure of monomeric FICD mutant L258D
6I7K	2.54	Crystal structure of monomeric FICD mutant L258D complexed with MgATP
6I7L	2.32	Crystal structure of monomeric FICD mutant L258D complexed with MgAMP-PNP
6ZMD	2.64	Crystal structure of HYPE covalently tethered to BiP bound to AMP-PNP
7B7Z	1.7	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 1)
7B80	1.87	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0034260	negative regulation of GTPase activity
Biological Process	GO:0018117	protein adenylylation
Biological Process	GO:0044602	protein deadenylylation
Biological Process	GO:1903894	regulation of IRE1-mediated unfolded protein response
Biological Process	GO:0034976	response to endoplasmic reticulum stress
Biological Process	GO:0006986	response to unfolded protein
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0030544	Hsp70 protein binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0044603	protein adenylylhydrolase activity
Molecular Function	GO:0070733	protein adenylyltransferase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0051087	protein-folding chaperone binding
Cellular Component	GO:0005789	endoplasmic reticulum membrane

InterPro	InterPro name
IPR003812	Fido domain
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR019734	Tetratricopeptide repeat
IPR036597	Fido-like domain superfamily
IPR040198	Fido domain-containing protein

Pfam	Pfam name
PF02661	Fic/DOC family

Location	ECO term	Pubmed
Endoplasmic reticulum membrane	ECO:0000269	PubMed:25601083

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	High	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
bronchus	ciliated cells (cell body)	Low	Approved
bronchus	ciliated cells (cilia axoneme)	Medium	Approved
bronchus	ciliated cells (tip of cilia)	Medium	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	ciliated cells (cilia axoneme)	Medium	Approved
fallopian tube	ciliated cells (tip of cilia)	High	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	High	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Medium	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	basal cells	Low	Approved
nasopharynx	ciliated cells (cell body)	Medium	Approved
nasopharynx	ciliated cells (cilia axoneme)	High	Approved
nasopharynx	ciliated cells (tip of cilia)	High	Approved
nasopharynx	goblet cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	High	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Low	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	Medium	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 1	peripheral nerve	Low	Approved
soft tissue 2	fibroblasts	Medium	Approved
soft tissue 2	peripheral nerve	Low	Approved
spleen	cells in red pulp	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	High	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	High	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved

Summary of Q9BVA6

Gene: FICD, HIP13, HYPE, UNQ3041/PRO9857
Protein: Protein adenylyltransferase FICD

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9BVA6

Gene: FICD, HIP13, HYPE, UNQ3041/PRO9857 Protein: Protein adenylyltransferase FICD

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: FICD, HIP13, HYPE, UNQ3041/PRO9857
Protein: Protein adenylyltransferase FICD