Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.1.1.-
Transferases;
Transferring one-carbon groups;
Methyltransferases;
2.1.1.220
Transferases;
Transferring one-carbon groups;
Methyltransferases;
tRNA (adenine58-N1)-methyltransferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2B25 | 2.5 | Human putative tRNA(1-methyladenosine)methyltransferase |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0080009 | mRNA methylation |
| Biological Process | GO:0070901 | mitochondrial tRNA methylation |
| Biological Process | GO:0051260 | protein homooligomerization |
| Molecular Function | GO:0061953 | mRNA (adenine-N1-)-methyltransferase activity |
| Molecular Function | GO:0016433 | rRNA (adenine) methyltransferase activity |
| Molecular Function | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0031515 | tRNA (m1A) methyltransferase complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-6787450 | tRNA modification in the mitochondrion | Leaf | R-HSA-8953854 | Metabolism of RNA |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion | ECO:0000269 | PubMed:23097428 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | High | Enhanced |
| appendix | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Low | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | adipocytes | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | glial cells | Medium | Enhanced |
| caudate | neuronal cells | High | Enhanced |
| cerebellum | Purkinje cells | Medium | Enhanced |
| cerebellum | cells in granular layer | Medium | Enhanced |
| cerebellum | cells in molecular layer | Medium | Enhanced |
| cerebral cortex | endothelial cells | Medium | Enhanced |
| cerebral cortex | glial cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | High | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | Medium | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | glandular cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | glial cells | Low | Enhanced |
| hippocampus | neuronal cells | High | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells type I | Medium | Enhanced |
| lung | alveolar cells type II | Low | Enhanced |
| lung | macrophages | Low | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| ovary | ovarian stroma cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | Langerhans | Medium | Enhanced |
| skin 1 | keratinocytes | Medium | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 1 | peripheral nerve | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Medium | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Low | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | High | Enhanced |
| testis | peritubular cells | Medium | Enhanced |
| testis | sertoli cells | Low | Enhanced |
| thyroid gland | glandular cells | High | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|