Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.5.1.-
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
3.5.1.98
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
histone deacetylase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1T64 | 1.9 | Crystal Structure of human HDAC8 complexed with Trichostatin A |
| 1T67 | 2.31 | Crystal Structure of Human HDAC8 complexed with MS-344 |
| 1T69 | 2.91 | Crystal Structure of human HDAC8 complexed with SAHA |
| 1VKG | 2.2 | Crystal Structure of Human HDAC8 complexed with CRA-19156 |
| 1W22 | 2.5 | Crystal structure of inhibited human HDAC8 |
| 2V5W | 2.0 | Crystal structure of HDAC8-substrate complex |
| 2V5X | 2.25 | Crystal structure of HDAC8-inhibitor complex |
| 3EW8 | 1.8 | Crystal Structure Analysis of human HDAC8 D101L variant |
| 3EWF | 2.5 | Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate. |
| 3EZP | 2.65 | Crystal Structure Analysis of human HDAC8 D101N variant |
| 3EZT | 2.85 | Crystal Structure Analysis of Human HDAC8 D101E Variant |
| 3F06 | 2.55 | Crystal Structure Analysis of Human HDAC8 D101A Variant. |
| 3F07 | 3.3 | Crystal Structure Analysis of Human HDAC8 complexed with APHA in a new monoclinic crystal form |
| 3F0R | 2.54 | Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form |
| 3MZ3 | 3.2 | Crystal structure of Co2+ HDAC8 complexed with M344 |
| 3MZ4 | 1.845 | Crystal structure of D101L Mn2+ HDAC8 complexed with M344 |
| 3MZ6 | 2.0 | Crystal structure of D101L Fe2+ HDAC8 complexed with M344 |
| 3MZ7 | 1.9 | Crystal structure of D101L Co2+ HDAC8 complexed with M344 |
| 3RQD | 2.143 | Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8 |
| 3SFF | 2.0 | Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor |
| 3SFH | 2.7 | Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor |
| 4QA0 | 2.242 | Crystal structure of C153F HDAC8 in complex with SAHA |
| 4QA1 | 1.92 | Crystal structure of A188T HDAC8 in complex with M344 |
| 4QA2 | 2.377 | Crystal structure of I243N HDAC8 in complex with SAHA |
| 4QA3 | 2.876 | Crystal structure of T311M HDAC8 in complex with Trichostatin A (TSA) |
| 4QA4 | 1.98 | Crystal structure of H334R HDAC8 in complex with M344 |
| 4QA5 | 1.76 | Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate |
| 4QA6 | 2.053 | Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate |
| 4QA7 | 2.31 | Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate |
| 4RN0 | 1.761 | Crystal structure of S39D HDAC8 in complex with a largazole analogue. |
| 4RN1 | 2.18 | Crystal structure of S39D HDAC8 in complex with a largazole analogue. |
| 4RN2 | 2.39 | Crystal structure of S39D HDAC8 in complex with a largazole analogue. |
| 5BWZ | 1.59 | Crystal structure of S39E HDAC8 in complex with Droxinostat |
| 5D1B | 2.9 | Crystal structure of G117E HDAC8 in complex with TSA |
| 5D1C | 1.422 | Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate |
| 5D1D | 2.011 | Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate |
| 5DC5 | 1.94 | Crystal structure of D176N HDAC8 in complex with M344 |
| 5DC6 | 1.553 | Crystal structure of D176N-Y306F HDAC8 in complex with a tetrapeptide substrate |
| 5DC7 | 2.3 | Crystal structure of D176A-Y306F HDAC8 in complex with a tetrapeptide substrate |
| 5DC8 | 1.3 | Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate |
| 5FCW | 1.979 | HDAC8 Complexed with a Hydroxamic Acid |
| 5THS | 1.9 | Crystal Structure of G302A HDAC8 in complex with M344 |
| 5THT | 2.407 | Crystal Structure of G303A HDAC8 in complex with M344 |
| 5THU | 1.95 | Crystal Structure of G304A HDAC8 in complex with M344 |
| 5THV | 1.868 | Crystal Structure of G305A HDAC8 in complex with M344 |
| 5VI6 | 1.237 | Crystal structure of histone deacetylase 8 in complex with trapoxin A |
| 6HSK | 2.096 | Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat |
| 6ODA | 2.88 | Crystal structure of HDAC8 in complex with compound 2 |
| 6ODB | 2.7 | Crystal structure of HDAC8 in complex with compound 3 |
| 6ODC | 2.8 | Crystal structure of HDAC8 in complex with compound 30 |
| 7JVU | 1.50048 | Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA |
| 7JVV | 1.84 | Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate |
| 7JVW | 2.40302 | Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0016575 | histone deacetylation |
| Biological Process | GO:0007064 | mitotic sister chromatid cohesion |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0032204 | regulation of telomere maintenance |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0160009 | histone decrotonylase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0033558 | protein lysine deacetylase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2467813 | Separation of Sister Chromatids | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-3214815 | HDACs deacetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-350054 | Notch-HLH transcription pathway | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Chromosome | ECO:0000269 | PubMed:10748112 |
| Cytoplasm | ECO:0000269 | PubMed:15772115 |
| Cytoplasm | ECO:0000269 | PubMed:16538051 |
| Nucleus | ECO:0000269 | PubMed:10748112 |
| Nucleus | ECO:0000269 | PubMed:14701748 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000003 | Multicystic kidney dysplasia |
| HP:0000028 | Cryptorchidism |
| HP:0000044 | Hypogonadotropic hypogonadism |
| HP:0000047 | Hypospadias |
| HP:0000054 | Micropenis |
| HP:0000059 | Hypoplastic labia majora |
| HP:0000076 | Vesicoureteral reflux |
| HP:0000083 | Renal insufficiency |
| HP:0000130 | Abnormality of the uterus |
| HP:0000135 | Hypogonadism |
| HP:0000175 | Cleft palate |
| HP:0000218 | High palate |
| HP:0000219 | Thin upper lip vermilion |
| HP:0000233 | Thin vermilion border |
| HP:0000248 | Brachycephaly |
| HP:0000252 | Microcephaly |
| HP:0000278 | Retrognathia |
| HP:0000294 | Low anterior hairline |
| HP:0000316 | Hypertelorism |
| HP:0000336 | Prominent supraorbital ridges |
| HP:0000343 | Long philtrum |
| HP:0000347 | Micrognathia |
| HP:0000365 | Hearing impairment |
| HP:0000368 | Low-set, posteriorly rotated ears |
| HP:0000400 | Macrotia |
| HP:0000405 | Conductive hearing impairment |
| HP:0000407 | Sensorineural hearing impairment |
| HP:0000413 | Atresia of the external auditory canal |
| HP:0000426 | Prominent nasal bridge |
| HP:0000453 | Choanal atresia |
| HP:0000455 | Broad nasal tip |
| HP:0000463 | Anteverted nares |
| HP:0000470 | Short neck |
| HP:0000482 | Microcornea |
| HP:0000486 | Strabismus |
| HP:0000490 | Deeply set eye |
| HP:0000498 | Blepharitis |
| HP:0000501 | Glaucoma |
| HP:0000506 | Telecanthus |
| HP:0000508 | Ptosis |
| HP:0000518 | Cataract |
| HP:0000527 | Long eyelashes |
| HP:0000540 | Hypermetropia |
| HP:0000545 | Myopia |
| HP:0000574 | Thick eyebrow |
| HP:0000639 | Nystagmus |
| HP:0000664 | Synophrys |
| HP:0000667 | Phthisis bulbi |
| HP:0000684 | Delayed eruption of teeth |
| HP:0000687 | Widely spaced teeth |
| HP:0000708 | Atypical behavior |
| HP:0000712 | Emotional lability |
| HP:0000717 | Autism |
| HP:0000722 | Compulsive behaviors |
| HP:0000739 | Anxiety |
| HP:0000767 | Pectus excavatum |
| HP:0000771 | Gynecomastia |
| HP:0000776 | Congenital diaphragmatic hernia |
| HP:0000786 | Primary amenorrhea |
| HP:0000823 | Delayed puberty |
| HP:0000965 | Cutis marmorata |
| HP:0001007 | Hirsutism |
| HP:0001182 | Tapered finger |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001263 | Global developmental delay |
| HP:0001276 | Hypertonia |
| HP:0001290 | Generalized hypotonia |
| HP:0001328 | Specific learning disability |
| HP:0001377 | Limited elbow extension |
| HP:0001385 | Hip dysplasia |
| HP:0001387 | Joint stiffness |
| HP:0001417 | X-linked inheritance |
| HP:0001423 | X-linked dominant inheritance |
| HP:0001508 | Failure to thrive |
| HP:0001511 | Intrauterine growth retardation |
| HP:0001557 | Prenatal movement abnormality |
| HP:0001622 | Premature birth |
| HP:0001629 | Ventricular septal defect |
| HP:0001631 | Atrial septal defect |
| HP:0001761 | Pes cavus |
| HP:0001763 | Pes planus |
| HP:0001770 | Toe syndactyly |
| HP:0001773 | Short foot |
| HP:0001883 | Talipes |
| HP:0001956 | Truncal obesity |
| HP:0001999 | Abnormal facial shape |
| HP:0002020 | Gastroesophageal reflux |
| HP:0002021 | Pyloric stenosis |
| HP:0002119 | Ventriculomegaly |
| HP:0002120 | Cerebral cortical atrophy |
| HP:0002162 | Low posterior hairline |
| HP:0002167 | Abnormality of speech or vocalization |
| HP:0002230 | Generalized hirsutism |
| HP:0002360 | Sleep disturbance |
| HP:0002465 | Poor speech |
| HP:0002553 | Highly arched eyebrow |
| HP:0002557 | Hypoplastic nipples |
| HP:0002566 | Intestinal malrotation |
| HP:0002580 | Volvulus |
| HP:0002714 | Downturned corners of mouth |
| HP:0002750 | Delayed skeletal maturation |
| HP:0002827 | Hip dislocation |
| HP:0002974 | Radioulnar synostosis |
| HP:0002983 | Micromelia |
| HP:0003042 | Elbow dislocation |
| HP:0003196 | Short nose |
| HP:0003764 | Nevus |
| HP:0003828 | Variable expressivity |
| HP:0004209 | Clinodactyly of the 5th finger |
| HP:0004322 | Short stature |
| HP:0005280 | Depressed nasal bridge |
| HP:0007018 | Attention deficit hyperactivity disorder |
| HP:0007360 | Aplasia/Hypoplasia of the cerebellum |
| HP:0007598 | Bilateral single transverse palmar creases |
| HP:0007665 | Curly eyelashes |
| HP:0008551 | Microtia |
| HP:0008734 | Decreased testicular size |
| HP:0008736 | Hypoplasia of penis |
| HP:0008850 | Severe postnatal growth retardation |
| HP:0008872 | Feeding difficulties in infancy |
| HP:0008897 | Postnatal growth retardation |
| HP:0009623 | Proximal placement of thumb |
| HP:0009830 | Peripheral neuropathy |
| HP:0009909 | Uplifted earlobe |
| HP:0010034 | Short 1st metacarpal |
| HP:0010300 | Abnormally low-pitched voice |
| HP:0010620 | Malar prominence |
| HP:0010864 | Intellectual disability, severe |
| HP:0010880 | Increased nuchal translucency |
| HP:0012165 | Oligodactyly |
| HP:0030680 | Abnormality of cardiovascular system morphology |
| HP:0040071 | Abnormal morphology of ulna |
| HP:0040082 | Happy demeanor |
| HP:0200055 | Small hand |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| cornelia de lange syndrome 5 | MONDO:0010471 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:300882 | |
| wilson-turner syndrome | MONDO:0010665 | E66 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:309585 | Orphanet:3459 |