Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.3.16
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-serine/threonine phosphatase
3.1.3.48
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-tyrosine-phosphatase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0045204 | MAPK export from nucleus |
| Biological Process | GO:0016311 | dephosphorylation |
| Biological Process | GO:0043508 | negative regulation of JUN kinase activity |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Molecular Function | GO:0008432 | JUN kinase binding |
| Molecular Function | GO:0033550 | MAP kinase tyrosine phosphatase activity |
| Molecular Function | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
| Molecular Function | GO:0051019 | mitogen-activated protein kinase binding |
| Molecular Function | GO:0048273 | mitogen-activated protein kinase p38 binding |
| Molecular Function | GO:0017018 | myosin phosphatase activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0008330 | protein tyrosine/threonine phosphatase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000340 | Dual specificity phosphatase, catalytic domain |
| IPR000387 | Tyrosine-specific protein phosphatases domain |
| IPR001763 | Rhodanese-like domain |
| IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
| IPR016130 | Protein-tyrosine phosphatase, active site |
| IPR020422 | Dual specificity protein phosphatase domain |
| IPR029021 | Protein-tyrosine phosphatase-like |
| IPR036873 | Rhodanese-like domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00581 | Rhodanese-like domain |
| PF00782 | Dual specificity phosphatase, catalytic domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-112409 | RAF-independent MAPK1/3 activation | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-5675221 | Negative regulation of MAPK pathway | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-9636569 | Suppression of autophagy | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9652817 | Signaling by MAPK mutants | Leaf | R-HSA-1643685 | Disease |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Low | Approved |
| cerebellum | Purkinje cells | Low | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | High | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells type II | Medium | Approved |
| lung | macrophages | High | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Low | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Low | Approved |
| testis | spermatogonia cells | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|