Structure
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1R42 | 2.2 | Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) |
| 1R4L | 3.0 | Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) |
| 2AJF | 2.9 | Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor |
| 3D0G | 2.8 | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus human strain complexed with human-civet chimeric receptor ACE2 |
| 3D0H | 3.1 | Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2 |
| 3D0I | 2.9 | Crystal structure of spike protein receptor-binding domain from the 2005-2006 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2 |
| 3KBH | 3.31 | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor |
| 3SCI | 2.9 | Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus human strain complexed with human receptor ACE2 |
| 3SCJ | 3.0 | Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human receptor ACE2 |
| 3SCK | 3.0 | Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2 |
Showing 1 to 10 of 195 entries
GO term
GO ontology
| GO term | GO description |
|---|---|---|
| Biological Process | GO:0002003 | angiotensin maturation |
| Biological Process | GO:0003051 | angiotensin-mediated drinking behavior |
| Biological Process | GO:0097746 | blood vessel diameter maintenance |
| Biological Process | GO:0060135 | maternal process involved in female pregnancy |
| Biological Process | GO:0061025 | membrane fusion |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000272 | negative regulation of signaling receptor activity |
| Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| Biological Process | GO:1905737 | positive regulation of L-proline import across plasma membrane |
| Biological Process | GO:0051957 | positive regulation of amino acid transport |
Showing 1 to 10 of 44 entries
Reactome
| Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9678110 | Attachment and Entry | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9679191 | Potential therapeutics for SARS | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9694614 | Attachment and Entry | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | Leaf | R-HSA-1643685 | Disease |
Showing 1 to 5 of 5 entries
Subcellular location
| Location
| ECO term
| Pubmed |
|---|---|---|
| Apical cell membrane | ECO:0000269 | PubMed:33432184 |
| Cell membrane | ECO:0000269 | PubMed:18424768 |
| Cell projection, cilium | ECO:0000269 | PubMed:33432184 |
| Cytoplasm | ECO:0000250 | |
| Secreted | ECO:0000269 | PubMed:15983030 |
| Secreted | ECO:0000269 | PubMed:33713620 |
Showing 1 to 6 of 6 entries
Interactor | Variant | Drug
Tissue and cell type
| Tissue
| Cell type
| Expression level | Reliability |
|---|---|---|---|
| appendix | enterocytes | Low | Enhanced |
| bronchus | ciliated cells (ciliary rootlets) | Medium | Enhanced |
| colon | enterocytes - Microvilli | High | Enhanced |
| duodenum | enterocytes | Low | Enhanced |
| duodenum | enterocytes - Microvilli | High | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| fallopian tube | ciliated cells (ciliary rootlets) | Medium | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| kidney | bowman's capsule | Medium | Enhanced |
| kidney | proximal tubules (cell body) | Medium | Enhanced |
Showing 1 to 10 of 23 entries