MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.4.17.-	Hydrolases; Acting on peptide bonds (peptidases); Metallocarboxypeptidases;
3.4.17.23	Hydrolases; Acting on peptide bonds (peptidases); Metallocarboxypeptidases; angiotensin-converting enzyme 2

Structure

PDB	Resolution (Å)	PDB name
8DM6	2.77	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
3D0I	2.9	Crystal structure of spike protein receptor-binding domain from the 2005-2006 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2
7T9L	2.66	Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7T9K	2.45	Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2
7R0Z	3.5	Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)
7DX9	3.6	Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (3 up RBD and 2 PD bound)
7SXZ	2.61	Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
7FDH	3.72	SARS-COV-2 Spike RBDMACSp25 binding to hACE2
7Y76	3.2	SIT1-ACE2-BA.5 RBD
7EFP	2.698	Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y)
6CS2	4.4	SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles
8DF5	2.7	SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab
7WGB	3.5	Neutral Omicron Spike Trimer in complex with ACE2
7YA1	3.11	Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)
7WPB	2.79	SARS-CoV-2 Omicron Variant RBD complexed with ACE2
7V82	2.8	Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 1
7KMS	3.64	Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4
7SY7	2.81	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417T mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
7R12	3.3	Dissociated S1 domain of Mink Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)
7VXM	3.6	SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C3 state
7V7Z	3.1	Cryo-EM structure of SARS-CoV-2 S-Beta variant (B.1.351) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form
3SCJ	3.0	Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human receptor ACE2
7ZF7	3.46	SARS-CoV-2 Omicron BA.2 RBD in complex with ACE2
7SN0	3.08	Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2
7UFK	2.38	Crystal structure of chimeric omicron RBD (strain BA.2) complexed with human ACE2
6ACJ	4.2	Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 2
7KNB	3.93	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4
7W98	3.6	SARS-CoV-2 Delta S-ACE2-C1
6M0J	2.45	Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2
3SCK	3.0	Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2
7E7E	3.8	The co-crystal structure of ACE2 with Fab
7DWX	8.3	Conformation 1 of S-ACE2-B0AT1 ternary complex
7W9B	3.4	SARS-CoV-2 Delta S-ACE2-C2b
7WVQ	4.04	Cryo-EM structure of SARS-CoV-2 Omicron Spike protein with human ACE2 receptor, C3 state
7R1A	3.9	Furin Cleaved Alpha Variant SARS-CoV-2 Spike in complex with 3 ACE2
6ACG	5.4	Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 1
7EKE	2.7	Structure of SARS-CoV-2 spike receptor-binding domain F486L mutation complexed with human ACE2
7PKI	2.94234	Crystal structure of human ACE2 bound to the spike receptor-binding domain from a cave bat sarbecovirus closely related to SARS-CoV-2.
7KNI	3.91	Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5
7A96	4.8	SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Anticlockwise Direction
7WSA	3.0	Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development
7VX5	3.8	ACE2-RBD in SARS-CoV-2 Kappa variant S-ACE2 complex
7DRV	3.09	Structural basis of SARS-CoV-2-closely-related bat coronavirus RaTG13 to hACE2
7WGC	3.6	Neutral Omicron Spike Trimer in complex with ACE2.
7WBL	3.4	Cryo-EM structure of human ACE2 complexed with SARS-CoV-2 Omicron RBD
7RPV	3.54	Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD
7XB0	2.9	Crystal structure of Omicron BA.2 RBD complexed with hACE2
8AQS	2.92	BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)
7V8B	3.2	Local refinement of SARS-CoV-2 S-Delta variant (B.1.617.2) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain
8DLQ	2.77	Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7V89	2.8	Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 1
7DDP	3.4	Cryo-EM structure of human ACE2 and GX/P2V/2017 RBD
8DLN	3.04	Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7XCH	3.4	Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (two-RBD-up state)
7WS9	2.9	Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development
7V87	3.3	Local refinement of SARS-CoV-2 S-Kappa variant (B.1.617.1) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain
7V80	3.9	Local refinement of SARS-CoV-2 S-Beta variant (B.1.351) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain
7EFR	2.494	Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y)
7FDI	3.12	SARS-COV-2 Spike RBDMACSp36 binding to hACE2
7U0N	2.61	Crystal structure of chimeric omicron RBD (strain BA.1) complexed with human ACE2
7Y75	3.1	SIT1-ACE2-BA.2 RBD
7YDI	3.98	SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2, focused refinement of RBD region
7WS8	3.0	Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development
8DLU	3.14	Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with human ACE2
7XBF	3.51	The complex structure of RshSTT182/200 RBD-insert2 bound to human ACE2
7XB1	2.7	Crystal structure of Omicron BA.3 RBD complexed with hACE2
7YR3	3.52	SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state2)
7WPA	2.77	SARS-CoV-2 Omicron Variant SPIKE trimer complexed with ACE2
7V84	3.0	Local refinement of SARS-CoV-2 S-Gamma variant (P.1) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain
6LZG	2.5	Structure of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2
7V83	2.8	Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2
8ASY	2.85	SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2
7JVO	2.2	Importin alpha bound to the C-terminus of ACE2
7XID	3.3	S-ECD (Omicron) in complex with PD of ACE2
7A98	5.4	SARS-CoV-2 Spike Glycoprotein with 3 ACE2 Bound
7MJM	2.83	Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain
7XO9	3.0	SARS-CoV-2 Omicron BA.2 Variant RBD complexed with human ACE2
7V61	3.2	ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
7YR2	3.3	SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state1)
7WBP	3.0	Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with its receptor human ACE2
7SY1	2.83	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
7DX6	3.0	S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (2 up RBD and 1 PD bound)
7L0N	2.78	Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
3D0H	3.1	Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2
3SCI	2.9	Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus human strain complexed with human receptor ACE2
7XCI	3.2	Cryo-EM structure of SARS-CoV-2 Omicron RBD in complex with human ACE2 ectodomain (local refinement)
7XWA	3.36	Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2
7VXF	3.6	SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C2B state
7MJN	3.29	Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7R11	3.5	Dissociated S1 domain of Beta Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)
7A97	4.4	SARS-CoV-2 Spike Glycoprotein with 2 ACE2 Bound
7DDO	3.4	Cryo-EM structure of human ACE2 and GD/1/2019 RBD
7KNE	3.85	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5
3SCL	3.0	Crystal structure of spike protein receptor-binding domain from SARS coronavirus epidemic strain complexed with human-civet chimeric receptor ACE2
7DX7	3.4	Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)
7DQA	2.8	Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex
7EKF	2.85	Structure of SARS-CoV-2 Alpha variant spike receptor-binding domain complexed with human ACE2
7W9C	3.2	SARS-CoV-2 Delta S-ACE2-C3
7XO8	3.48	SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound
7V86	2.8	Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form
7WK5	3.66	Cryo-EM structure of Omicron S-ACE2, C2 state
7V8A	2.7	Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2
7EKC	2.8	Structure of SARS-CoV-2 Gamma variant spike receptor-binding domain complexed with human ACE2
7TF0	3.02	Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) spike protein in complex with human ACE2
7SY0	3.0	Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7W99	3.4	SARS-CoV-2 Delta S-ACE2-C2a
7XO7	3.38	SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two human ACE2 Bound
7TEZ	3.27	Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
8DLM	2.89	Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with human ACE2
7TN0	2.85	SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab
7EKG	2.63	Structure of SARS-CoV-2 Beta variant spike receptor-binding domain complexed with human ACE2
7A92	4.2	Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Unmasked Refinement)
6VW1	2.68	Structure of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2
1R42	2.2	Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)
7SY4	3.35	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7DF4	3.8	SARS-CoV-2 S-ACE2 complex
6M17	2.9	The 2019-nCoV RBD/ACE2-B0AT1 complex
7XBG	3.37	The crystal structure of RshSTT182/200 RBD-insert2-T346R-Y496G mutant in complex with human ACE2
7VIB	3.2	Crystal structure of human ACE2 and GX/P2V RBD
7SY3	2.95	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
7DX5	3.3	S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (1 up RBD and 1 PD bound)
7XBH	3.02	The complex structure of RshSTT182/200 RBD bound to human ACE2
7YA0	3.1	Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (S-6P-RRAR)
8DV1	3.4	SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
7VXC	3.9	SARS-CoV-2 Kappa variant spike protein in C3 state
7EDJ	3.3	Cryo-EM structure of SARS-CoV-2 S-UK variant (B.1.1.7) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain
7A94	3.9	SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound
7R10	4.0	Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2
7NXC	3.14	Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with ACE2
7V88	3.3	Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form
7WNM	2.7	Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q)
7WK6	3.67	Cryo-EM structure of SARS-CoV-2 Omicron spike protein with human ACE2 (focus refinement on RBD-1/ACE2)
7W9I	3.4	SARS-CoV-2 Delta S-RBD-ACE2
7VXD	4.0	SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C1 state
7WHH	2.6	Crystal structure of SARS-CoV-2 omicron RBD and human ACE2
7VX4	3.9	ACE2-RBD in SARS-CoV-2 Beta variant S-ACE2 complex
7L7F	3.24	Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
6M18	2.9	ACE2-B0AT1 complex
7SXY	2.79	Cryo-EM structure of the SARS-CoV-2 D614G mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7WBQ	3.34	Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant spike glycoprotein in complex with its receptor human ACE2
7P8J	6.585	Receptor-binding domain (RBD) of the spike protein of the bat coronavirus RaTG13 virus in complex with the extracellular domain of human angiotensin-converting enzyme 2 (ACE2) - Crystal form 2
7SY8	3.14	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417T mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7SY6	2.81	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7P19	3.24	Crystal structure of SARS-CoV-2 RBD Q498Y complexed with human ACE2
6ACK	4.5	Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 3
7P55		NMR structure of human ACE2 21-42 fragment in HFIP/water 50/50 v/v
7KJ3	3.7	SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound
7XCP	3.05	Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab
7EKH	2.4	Structure of SARS-CoV-2 spike receptor-binding domain Y453F mutation complexed with human ACE2
7TEX	3.27	Cryo-EM structure of SARS-CoV-2 Delta (B.1.617.2) spike protein in complex with human ACE2
3D0G	2.8	Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus human strain complexed with human-civet chimeric receptor ACE2
7KNH	3.74	Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5
7SY2	3.11	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
7WVP	3.7	Cryo-EM structure of SARS-CoV-2 Omicron Spike protein with human ACE2 receptor, C2 state
8DV2	3.5	SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
7YEG	3.73	SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2
7VXB	3.9	SARS-CoV-2 Kappa variant spike protein in C2b state
7KMZ	3.62	Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4
8E7M	3.3	Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04
7CT5	4.0	S protein of SARS-CoV-2 in complex bound with T-ACE2
3KBH	3.31	Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor
7P8I	4.5	Receptor-binding domain (RBD) of the spike protein of the bat coronavirus RaTG13 virus in complex with the extracellular domain of human angiotensin-converting enzyme 2 (ACE2) - Crystal form 1
8DLP	2.64	Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2
7BH9	2.9	SARS-CoV-2 RBD-62 in complex with ACE2 peptidase domain
8DLK	3.04	Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7Y9Z	2.85	Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state)
6M1D	4.5	ACE2-B0AT1 complex, open conformation
8DM5	2.51	Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2
7SXX	2.66	Cryo-EM structure of the SARS-CoV-2 D614G mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
2AJF	2.9	Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor
7LO4	2.465	SARS-CoV-2 spike receptor-binding domain with a G485R mutation in complex with human ACE2
7KMB	3.39	ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4
7V81	3.2	Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form
7DMU	3.2	Structure of SARS-CoV-2 spike receptor-binding domain complexed with high affinity ACE2 mutant 3N39
7WK4	3.69	Cryo-EM structure of SARS-CoV-2 Omicron spike protein with ACE2, C1 state
7DX8	2.9	Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)
7SY5	2.59	Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
7KJ2	3.6	SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound
7DX4	3.6	The structure of FC08 Fab-hA.CE2-RBD complex
1R4L	3.0	Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)
7FEM	4.1	SARS-CoV-2 B.1.1.7 S-ACE2 complex
7FDG	3.69	SARS-COV-2 Spike RBDMACSp6 binding to hACE2
7A95	4.3	SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Clockwise Direction
8DLV	3.11	Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7V85	3.3	Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form
7A91	3.6	Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)
7VXA	3.9	SARS-CoV-2 Kappa variant spike protein in complex with ACE2, state C2a
7KJ4	3.4	SARS-CoV-2 Spike Glycoprotein with three ACE2 Bound
8DLJ	2.91	Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with human ACE2
7WPC	2.57	The second RBD of SARS-CoV-2 Omicron Variant in complexed with RBD-ACE2
7ZDQ	3.2	Cryo-EM structure of Human ACE2 bound to a high-affinity SARS CoV-2 mutant
7VXK	3.7	SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C2A state
7VX9	4.0	SARS-CoV-2 Kappa variant spike protein in complex wth ACE2, state C1
7TEW	3.52	Cryo-EM structure of SARS-CoV-2 Delta (B.1.617.2) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
7XAZ	3.0	Crystal structure of Omicron BA.1.1 RBD complexed with hACE2

GO term

GO ontology	GO term	GO description
Biological Process	GO:0002003	angiotensin maturation
Biological Process	GO:0003051	angiotensin-mediated drinking behavior
Biological Process	GO:0097746	blood vessel diameter maintenance
Biological Process	GO:0060135	maternal process involved in female pregnancy
Biological Process	GO:0061025	membrane fusion
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade
Biological Process	GO:2000272	negative regulation of signaling receptor activity
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation
Biological Process	GO:1905737	positive regulation of L-proline import across plasma membrane
Biological Process	GO:0051957	positive regulation of amino acid transport
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction
Biological Process	GO:1903598	positive regulation of gap junction assembly
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell
Biological Process	GO:0046813	receptor-mediated virion attachment to host cell
Biological Process	GO:1903779	regulation of cardiac conduction
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0001817	regulation of cytokine production
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
Biological Process	GO:0022898	regulation of transmembrane transporter activity
Biological Process	GO:0019229	regulation of vasoconstriction
Biological Process	GO:0015827	tryptophan transport
Biological Process	GO:0046718	viral entry into host cell
Biological Process	GO:0019058	viral life cycle
Molecular Function	GO:0004180	carboxypeptidase activity
Molecular Function	GO:0004175	endopeptidase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0004181	metallocarboxypeptidase activity
Molecular Function	GO:0008237	metallopeptidase activity
Molecular Function	GO:0008241	peptidyl-dipeptidase activity
Molecular Function	GO:0001618	virus receptor activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0031526	brush border membrane
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0030666	endocytic vesicle membrane
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR001548	Peptidase M2, peptidyl-dipeptidase A
IPR031588	Collectrin domain

Pfam	Pfam name
PF01401	Angiotensin-converting enzyme
PF16959	Renal amino acid transporter

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9678110	Attachment and Entry	Leaf	R-HSA-1643685	Disease
R-HSA-9679191	Potential therapeutics for SARS	Leaf	R-HSA-1643685	Disease
R-HSA-9694614	Attachment and Entry	Leaf	R-HSA-1643685	Disease
R-HSA-9733458	Induction of Cell-Cell Fusion	Leaf	R-HSA-1643685	Disease

Location	ECO term	Pubmed
Apical cell membrane	ECO:0000269	PubMed:33432184
Cell membrane	ECO:0000269	PubMed:18424768
Cell projection, cilium	ECO:0000269	PubMed:33432184
Cytoplasm	ECO:0000250
Secreted	ECO:0000269	PubMed:15983030
Secreted	ECO:0000269	PubMed:33713620

Tissue	Cell type	Expression level	Reliability
appendix	enterocytes	Low	Enhanced
bronchus	ciliated cells (ciliary rootlets)	Medium	Enhanced
colon	enterocytes - Microvilli	High	Enhanced
duodenum	enterocytes	Low	Enhanced
duodenum	enterocytes - Microvilli	High	Enhanced
epididymis	glandular cells	Medium	Enhanced
fallopian tube	ciliated cells (ciliary rootlets)	Medium	Enhanced
gallbladder	glandular cells	High	Enhanced
kidney	bowman's capsule	Medium	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
kidney	proximal tubules (microvilli)	High	Enhanced
nasopharynx	ciliated cells (ciliary rootlets)	Medium	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
placenta	decidual cells	Low	Enhanced
placenta	endothelial cells	Medium	Enhanced
placenta	hofbauer cells	Medium	Enhanced
placenta	syncytiotrophoblasts - microvilli	High	Enhanced
rectum	enterocytes - Microvilli	High	Enhanced
seminal vesicle	glandular cells	Medium	Enhanced
small intestine	enterocytes	Low	Enhanced
small intestine	enterocytes - Microvilli	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	sertoli cells	High	Enhanced

Summary of Q9BYF1

Gene: ACE2, UNQ868/PRO1885
Protein: Angiotensin-converting enzyme 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9BYF1

Gene: ACE2, UNQ868/PRO1885 Protein: Angiotensin-converting enzyme 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ACE2, UNQ868/PRO1885
Protein: Angiotensin-converting enzyme 2