MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
4.2.1.152	Lyases; Carbon-oxygen lyases; Hydro-lyases; hydroperoxy icosatetraenoate dehydratase
5.4.4.7	Isomerases; Intramolecular transferases; Transferring hydroxy groups; hydroperoxy icosatetraenoate isomerase

PDB	Resolution (Å)	PDB name
6VB2	1.41	HLA-B*15:02 complexed with a synthetic peptide

GO ontology	GO term	GO description
Biological Process	GO:0019369	arachidonic acid metabolic process
Biological Process	GO:0046513	ceramide biosynthetic process
Biological Process	GO:0061436	establishment of skin barrier
Biological Process	GO:0045444	fat cell differentiation
Biological Process	GO:0051122	hepoxilin biosynthetic process
Biological Process	GO:0043651	linoleic acid metabolic process
Biological Process	GO:0034440	lipid oxidation
Biological Process	GO:0019372	lipoxygenase pathway
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway
Biological Process	GO:0019233	sensory perception of pain
Biological Process	GO:0006665	sphingolipid metabolic process
Molecular Function	GO:0051120	hepoxilin A3 synthase activity
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity
Molecular Function	GO:0106255	hydroperoxy icosatetraenoate isomerase activity
Molecular Function	GO:0050486	intramolecular transferase activity, transferring hydroxy groups
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Cellular Component	GO:0005829	cytosol

InterPro	InterPro name
IPR000907	Lipoxygenase
IPR001024	PLAT/LH2 domain
IPR001885	Lipoxygenase, mammalian
IPR013819	Lipoxygenase, C-terminal
IPR020833	Lipoxygenase, iron binding site
IPR020834	Lipoxygenase, conserved site
IPR036226	Lipoxigenase, C-terminal domain superfamily
IPR036392	PLAT/LH2 domain superfamily
IPR042062	Lipoxygenase, vertebrates, PLAT domain

Pfam	Pfam name
PF00305	Lipoxygenase
PF01477	PLAT/LH2 domain

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000083	Renal insufficiency
HP:0000164	Abnormality of the dentition
HP:0000232	Everted lower lip vermilion
HP:0000365	Hearing impairment
HP:0000389	Chronic otitis media
HP:0000491	Keratitis
HP:0000656	Ectropion
HP:0000958	Dry skin
HP:0000962	Hyperkeratosis
HP:0000966	Hypohidrosis
HP:0000970	Anhidrosis
HP:0000982	Palmoplantar keratoderma
HP:0000989	Pruritus
HP:0001019	Erythroderma
HP:0001376	Limitation of joint mobility
HP:0001508	Failure to thrive
HP:0001510	Growth delay
HP:0001595	Abnormal hair morphology
HP:0001596	Alopecia
HP:0001597	Abnormality of the nail
HP:0001792	Small nail
HP:0001816	Thin nail
HP:0001831	Short toe
HP:0001944	Dehydration
HP:0002046	Heat intolerance
HP:0002205	Recurrent respiratory infections
HP:0003241	External genital hypoplasia
HP:0003470	Paralysis
HP:0003577	Congenital onset
HP:0004322	Short stature
HP:0006889	Intellectual disability, borderline
HP:0007431	Congenital ichthyosiform erythroderma
HP:0007479	Congenital nonbullous ichthyosiform erythroderma
HP:0008064	Ichthyosis
HP:0008070	Sparse hair
HP:0009381	Short finger
HP:0010783	Erythema
HP:0011039	Abnormal helix morphology
HP:0012472	Eclabion
HP:0025092	Epidermal acanthosis
HP:0025114	Hypergranulosis
HP:0033252	Palmar hyperlinearity
HP:0100543	Cognitive impairment
HP:0100679	Lack of skin elasticity
HP:0100758	Gangrene
HP:0100806	Sepsis
HP:0100840	Aplasia/Hypoplasia of the eyebrow
HP:0200020	Corneal erosion

Tissue	Cell type	Expression level	Reliability
breast	glandular cells	Low	Enhanced
skin 1	keratinocytes	Medium	Enhanced
skin 2	epidermal cells	Medium	Enhanced
testis	elongated or late spermatids	High	Enhanced
testis	sertoli cells	Low	Enhanced