Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.1.1.370
Transferases;
Transferring one-carbon groups;
Methyltransferases;
[histone H3]-lysine4 N-dimethyltransferase
2.1.1.371
Transferases;
Transferring one-carbon groups;
Methyltransferases;
[histone H3]-lysine27 N-dimethyltransferase
PDB | Resolution (Å) | PDB name |
---|---|---|
2DAQ | Solution structure of second PWWP domain of WHSC1L1 protein | |
2NCZ | Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide | |
2ND1 | Solution NMR structures of BRD4 ET domain in complex with NSD3_3 peptide | |
4GND | 2.27 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains |
4GNE | 1.47 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7 |
4GNF | 1.55 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15 |
4GNG | 1.73 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide |
4RXJ | 2.1 | crystal structure of WHSC1L1-PWWP2 |
5UPD | 1.8 | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) |
6CEN | 1.61 | Crystal Structure of WHSC1L1 in Complex with Inhibitor PEP21 |
6G24 | 2.1 | X-ray structure of NSD3-PWWP1 in complex with compound 3 |
6G25 | 1.432 | X-ray structure of NSD3-PWWP1 in complex with compound 4 |
6G27 | 1.65 | X-ray structure of NSD3-PWWP1 in complex with compound 5 |
6G29 | 1.7 | X-ray structure of NSD3-PWWP1 in complex with compound 6 |
6G2B | 1.61 | X-ray structure of NSD3-PWWP1 in complex with compound 8 |
6G2C | 1.76 | X-ray structure of NSD3-PWWP1 in complex with compound 9 |
6G2E | 1.85 | X-ray structure of NSD3-PWWP1 in complex with compound 13 |
6G2F | 1.74 | X-ray structure of NSD3-PWWP1 in complex with compound 16 |
6G2O | 1.81 | X-ray structure of NSD3-PWWP1 in complex with compound BI-9321 |
6G3P | 2.8 | X-ray structure of seleno-methionine labelled NSD3-PWWP1 |
6G3T | 2.53 | X-ray structure of NSD3-PWWP1 |
7CRP | 3.2 | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) |
7CRQ | 3.15 | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) |
7CRR | 3.48 | Native NSD3 bound to 187-bp nucleosome |
7JYN | Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0032259 | methylation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Molecular Function | GO:0140952 | histone H3K27 dimethyltransferase activity |
Molecular Function | GO:0046975 | histone H3K36 methyltransferase activity |
Molecular Function | GO:0140946 | histone H3K4 dimethyltransferase activity |
Molecular Function | GO:0046872 | metal ion binding |
Molecular Function | GO:0140537 | transcription regulator activator activity |
Cellular Component | GO:0000785 | chromatin |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
InterPro | InterPro name |
---|---|
IPR000313 | PWWP domain |
IPR001214 | SET domain |
IPR001965 | Zinc finger, PHD-type |
IPR003616 | Post-SET domain |
IPR006560 | AWS domain |
IPR011011 | Zinc finger, FYVE/PHD-type |
IPR013083 | Zinc finger, RING/FYVE/PHD-type |
IPR019786 | Zinc finger, PHD-type, conserved site |
IPR019787 | Zinc finger, PHD-finger |
IPR041306 | NSD, Cys-His rich domain |
IPR046341 | SET domain superfamily |
IPR047451 | Histone-lysine N-methyltransferase NSD3, first PWWP domain |
IPR047453 | Histone-lysine N-methyltransferase NSD3, second PWWP domain |
IPR047456 | Histone-lysine N-methyltransferase NSD3, second PHD finger |
IPR047458 | Histone-lysine N-methyltransferase NSD3, fourth PHD finger |
IPR047461 | Histone-lysine N-methyltransferase NSD3, SET domain |
IPR047527 | Histone-lysine N-methyltransferase NSD3, fifth PHD finger |
Pfam | Pfam name |
---|---|
PF00855 | PWWP domain |
PF00856 | SET domain |
PF17907 | AWS domain |
PF17982 | NSD Cys-His rich domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-3214841 | PKMTs methylate histone lysines | Leaf | R-HSA-4839726 | Chromatin organization |
Location | ECO term | Pubmed |
---|---|---|
Chromosome | ECO:0000250 | |
Nucleus | ECO:0000250 |