Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.1.1.370
Transferases;
Transferring one-carbon groups;
Methyltransferases;
[histone H3]-lysine4 N-dimethyltransferase
2.1.1.371
Transferases;
Transferring one-carbon groups;
Methyltransferases;
[histone H3]-lysine27 N-dimethyltransferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2DAQ | Solution structure of second PWWP domain of WHSC1L1 protein | |
| 2NCZ | Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide | |
| 2ND1 | Solution NMR structures of BRD4 ET domain in complex with NSD3_3 peptide | |
| 4GND | 2.27 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains |
| 4GNE | 1.47 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7 |
| 4GNF | 1.55 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15 |
| 4GNG | 1.73 | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide |
| 4RXJ | 2.1 | crystal structure of WHSC1L1-PWWP2 |
| 5UPD | 1.8 | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) |
| 6CEN | 1.61 | Crystal Structure of WHSC1L1 in Complex with Inhibitor PEP21 |
| 6G24 | 2.1 | X-ray structure of NSD3-PWWP1 in complex with compound 3 |
| 6G25 | 1.432 | X-ray structure of NSD3-PWWP1 in complex with compound 4 |
| 6G27 | 1.65 | X-ray structure of NSD3-PWWP1 in complex with compound 5 |
| 6G29 | 1.7 | X-ray structure of NSD3-PWWP1 in complex with compound 6 |
| 6G2B | 1.61 | X-ray structure of NSD3-PWWP1 in complex with compound 8 |
| 6G2C | 1.76 | X-ray structure of NSD3-PWWP1 in complex with compound 9 |
| 6G2E | 1.85 | X-ray structure of NSD3-PWWP1 in complex with compound 13 |
| 6G2F | 1.74 | X-ray structure of NSD3-PWWP1 in complex with compound 16 |
| 6G2O | 1.81 | X-ray structure of NSD3-PWWP1 in complex with compound BI-9321 |
| 6G3P | 2.8 | X-ray structure of seleno-methionine labelled NSD3-PWWP1 |
| 6G3T | 2.53 | X-ray structure of NSD3-PWWP1 |
| 7CRP | 3.2 | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) |
| 7CRQ | 3.15 | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) |
| 7CRR | 3.48 | Native NSD3 bound to 187-bp nucleosome |
| 7JYN | Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Molecular Function | GO:0140952 | histone H3K27 dimethyltransferase activity |
| Molecular Function | GO:0046975 | histone H3K36 methyltransferase activity |
| Molecular Function | GO:0140946 | histone H3K4 dimethyltransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0140537 | transcription regulator activator activity |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000313 | PWWP domain |
| IPR001214 | SET domain |
| IPR001965 | Zinc finger, PHD-type |
| IPR003616 | Post-SET domain |
| IPR006560 | AWS domain |
| IPR011011 | Zinc finger, FYVE/PHD-type |
| IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| IPR019786 | Zinc finger, PHD-type, conserved site |
| IPR019787 | Zinc finger, PHD-finger |
| IPR041306 | NSD, Cys-His rich domain |
| IPR046341 | SET domain superfamily |
| IPR047451 | Histone-lysine N-methyltransferase NSD3, first PWWP domain |
| IPR047453 | Histone-lysine N-methyltransferase NSD3, second PWWP domain |
| IPR047456 | Histone-lysine N-methyltransferase NSD3, second PHD finger |
| IPR047458 | Histone-lysine N-methyltransferase NSD3, fourth PHD finger |
| IPR047461 | Histone-lysine N-methyltransferase NSD3, SET domain |
| IPR047527 | Histone-lysine N-methyltransferase NSD3, fifth PHD finger |
| Pfam
|
Pfam name |
|---|---|
| PF00855 | PWWP domain |
| PF00856 | SET domain |
| PF17907 | AWS domain |
| PF17982 | NSD Cys-His rich domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-3214841 | PKMTs methylate histone lysines | Leaf | R-HSA-4839726 | Chromatin organization |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Chromosome | ECO:0000250 | |
| Nucleus | ECO:0000250 |