Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
4.3.1.17
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases;
L-serine ammonia-lyase
4.3.1.18
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases;
D-serine ammonia-lyase
5.1.1.18
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives;
serine racemase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3L6B | 1.5 | X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor |
| 3L6R | 1.7 | The structure of mammalian serine racemase: Evidence for conformational changes upon inhibitor binding |
| 5X2L | 1.806 | Crystal Structure of Human Serine Racemase |
| 6SLH | 1.89 | Conformational flexibility within the small domain of human serine racemase. |
| 6ZSP | 1.6 | Human serine racemase bound to ATP and malonate. |
| 6ZUJ | 1.8 | Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen). |
| 7NBC | 1.71 | Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen. |
| 7NBD | 1.865 | Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen. |
| 7NBF | 1.6 | Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen. |
| 7NBG | 1.53 | Crystal structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen. |
| 7NBH | 1.77 | Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen. |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0070179 | D-serine biosynthetic process |
| Biological Process | GO:0070178 | D-serine metabolic process |
| Biological Process | GO:0006563 | L-serine metabolic process |
| Biological Process | GO:0007568 | aging |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0042866 | pyruvate biosynthetic process |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0043278 | response to morphine |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0009069 | serine family amino acid metabolic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008721 | D-serine ammonia-lyase activity |
| Molecular Function | GO:0003941 | L-serine ammonia-lyase activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0016594 | glycine binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0030378 | serine racemase activity |
| Molecular Function | GO:0018114 | threonine racemase activity |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-977347 | Serine biosynthesis | Leaf | R-HSA-1430728 | Metabolism |