Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
2.3.1.258
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
N-terminal methionine Nα-acetyltransferase NatE
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2OB0 | 1.8 | Human MAK3 homolog in complex with Acetyl-CoA |
| 2PSW | 2.1 | Human MAK3 homolog in complex with CoA |
| 3TFY | 2.75 | Naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and CoA |
| 4X5K | 2.494 | Human NAA50 complex with coenzyme A and an acetylated peptide |
| 6PPL | 3.02 | Cryo-EM structure of human NatE complex (NatA/Naa50) |
| 6PW9 | 4.03 | Cryo-EM structure of human NatE/HYPK complex |
| 6WF3 | 2.291 | Crystal structure of human Naa50 in complex with a cofactor derived inhibitor (compound 1) |
| 6WF5 | 2.04 | Crystal structure of human Naa50 in complex with a truncated cofactor derived inhibitor (compound 2) |
| 6WFG | 2.16 | Crystal structure of human Naa50 in complex with an inhibitor (compound 3) identified using DNA encoded library technology |
| 6WFK | 1.87 | Crystal structure of human Naa50 in complex with CoA and an inhibitor (compound 4a) identified using DNA encoded library technology |
| 6WFN | 1.07 | Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4a) identified using DNA encoded library technology |
| 6WFO | 1.85 | Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4b) identified using DNA encoded library technology |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006474 | N-terminal protein amino acid acetylation |
| Biological Process | GO:0034087 | establishment of mitotic sister chromatid cohesion |
| Biological Process | GO:0007064 | mitotic sister chromatid cohesion |
| Biological Process | GO:0071962 | mitotic sister chromatid cohesion, centromeric |
| Molecular Function | GO:0010485 | histone H4 acetyltransferase activity |
| Molecular Function | GO:0004596 | peptide alpha-N-acetyltransferase activity |
| Molecular Function | GO:0052858 | peptidyl-lysine acetyltransferase activity |
| Cellular Component | GO:0031415 | NatA complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:16507339 |
| Cytoplasm | ECO:0000269 | PubMed:17502424 |
| Cytoplasm | ECO:0000269 | PubMed:25732826 |
| Cytoplasm | ECO:0000269 | PubMed:27422821 |
| Nucleus | ECO:0000269 | PubMed:25732826 |