Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0000076 | DNA replication checkpoint signaling |
| Biological Process | GO:0071163 | DNA replication preinitiation complex assembly |
| Biological Process | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:2000104 | negative regulation of DNA-templated DNA replication |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:2000105 | positive regulation of DNA-templated DNA replication |
| Biological Process | GO:0035563 | positive regulation of chromatin binding |
| Biological Process | GO:1902595 | regulation of DNA replication origin binding |
| Biological Process | GO:0030174 | regulation of DNA-templated DNA replication initiation |
| Biological Process | GO:0033262 | regulation of nuclear cell cycle DNA replication |
| Biological Process | GO:0072708 | response to sorbitol |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0070182 | DNA polymerase binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR014939 | CDT1 Geminin-binding domain-like |
| IPR032054 | DNA replication factor Cdt1, C-terminal |
| IPR036390 | Winged helix DNA-binding domain superfamily |
| IPR038090 | DNA replication factor Cdt1, C-terminal WH domain superfamily |
| IPR045173 | DNA replication factor Cdt1 |
| Pfam
|
Pfam name |
|---|---|
| PF08839 | DNA replication factor CDT1 like |
| PF16679 | DNA replication factor Cdt1 C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-68867 | Assembly of the pre-replicative complex | Internal node | R-HSA-69306 | DNA Replication |
| R-HSA-68949 | Orc1 removal from chromatin | Leaf | R-HSA-69306 | DNA Replication |
| R-HSA-68962 | Activation of the pre-replicative complex | Leaf | R-HSA-69306 | DNA Replication |
| R-HSA-69052 | Switching of origins to a post-replicative state | Internal node | R-HSA-69306 | DNA Replication |
| R-HSA-69205 | G1/S-Specific Transcription | Leaf | R-HSA-1640170 | Cell Cycle |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Chromosome, centromere, kinetochore | ECO:0000269 | PubMed:22581055 |
| Nucleus | ECO:0000269 | PubMed:11125146 |
| Nucleus | ECO:0000269 | PubMed:26842564 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000028 | Cryptorchidism |
| HP:0000039 | Epispadias |
| HP:0000047 | Hypospadias |
| HP:0000059 | Hypoplastic labia majora |
| HP:0000060 | Clitoral hypoplasia |
| HP:0000064 | Hypoplastic labia minora |
| HP:0000160 | Narrow mouth |
| HP:0000175 | Cleft palate |
| HP:0000176 | Submucous cleft hard palate |
| HP:0000179 | Thick lower lip vermilion |
| HP:0000193 | Bifid uvula |
| HP:0000252 | Microcephaly |
| HP:0000278 | Retrognathia |
| HP:0000327 | Hypoplasia of the maxilla |
| HP:0000347 | Micrognathia |
| HP:0000356 | Abnormality of the outer ear |
| HP:0000358 | Posteriorly rotated ears |
| HP:0000365 | Hearing impairment |
| HP:0000369 | Low-set ears |
| HP:0000413 | Atresia of the external auditory canal |
| HP:0000772 | Abnormal rib morphology |
| HP:0000895 | Lateral clavicle hook |
| HP:0001249 | Intellectual disability |
| HP:0001263 | Global developmental delay |
| HP:0001328 | Specific learning disability |
| HP:0001363 | Craniosynostosis |
| HP:0001508 | Failure to thrive |
| HP:0001510 | Growth delay |
| HP:0001511 | Intrauterine growth retardation |
| HP:0002094 | Dyspnea |
| HP:0002097 | Emphysema |
| HP:0002098 | Respiratory distress |
| HP:0002705 | High, narrow palate |
| HP:0002750 | Delayed skeletal maturation |
| HP:0002816 | Genu recurvatum |
| HP:0002878 | Respiratory failure |
| HP:0003042 | Elbow dislocation |
| HP:0003100 | Slender long bone |
| HP:0003187 | Breast hypoplasia |
| HP:0003510 | Severe short stature |
| HP:0003561 | Birth length less than 3rd percentile |
| HP:0003577 | Congenital onset |
| HP:0004209 | Clinodactyly of the 5th finger |
| HP:0004322 | Short stature |
| HP:0005692 | Joint hyperflexibility |
| HP:0005930 | Abnormal epiphysis morphology |
| HP:0006443 | Patellar aplasia |
| HP:0006660 | Aplastic clavicle |
| HP:0008551 | Microtia |
| HP:0008665 | Clitoral hypertrophy |
| HP:0008736 | Hypoplasia of penis |
| HP:0009892 | Anotia |
| HP:0009939 | Mandibular aplasia |
| HP:0011267 | Microtia, third degree |
| HP:0011968 | Feeding difficulties |
| HP:0012471 | Thick vermilion border |
| HP:0100490 | Camptodactyly of finger |
| HP:0100783 | Breast aplasia |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | High | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | High | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | High | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | endothelial cells | High | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | High | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | High | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | High | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Medium | Approved |
| lung | alveolar cells | High | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | High | Approved |
| ovary | ovarian stroma cells | High | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | High | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | High | Approved |
| skin 1 | Langerhans | High | Approved |
| skin 1 | fibroblasts | High | Approved |
| skin 1 | keratinocytes | High | Approved |
| skin 1 | melanocytes | High | Approved |
| skin 2 | epidermal cells | High | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | fibroblasts | High | Approved |
| soft tissue 2 | fibroblasts | High | Approved |
| soft tissue 2 | peripheral nerve | High | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| meier-gorlin syndrome 4 | MONDO:0013431 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:613804 |