MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
1.1.1.-	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor;
1.1.1.181	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; cholest-5-ene-3β,7α-diol 3β-dehydrogenase

Publications

GO ontology	GO term	GO description
Biological Process	GO:0035754	B cell chemotaxis
Biological Process	GO:0006699	bile acid biosynthetic process
Molecular Function	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
Molecular Function	GO:0047016	cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
Molecular Function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005811	lipid droplet

InterPro	InterPro name
IPR002225	3-beta hydroxysteroid dehydrogenase/isomerase
IPR036291	NAD(P)-binding domain superfamily

Pfam	Pfam name
PF01073	3-beta hydroxysteroid dehydrogenase/isomerase family

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Endoplasmic reticulum membrane

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000662	Nyctalopia
HP:0000939	Osteoporosis
HP:0000952	Jaundice
HP:0000989	Pruritus
HP:0001080	Biliary tract abnormality
HP:0001394	Cirrhosis
HP:0001399	Hepatic failure
HP:0001406	Intrahepatic cholestasis
HP:0001508	Failure to thrive
HP:0001744	Splenomegaly
HP:0001892	Abnormal bleeding
HP:0001928	Abnormality of coagulation
HP:0002014	Diarrhea
HP:0002024	Malabsorption
HP:0002239	Gastrointestinal hemorrhage
HP:0002240	Hepatomegaly
HP:0002570	Steatorrhea
HP:0002630	Fat malabsorption
HP:0002748	Rickets
HP:0002908	Conjugated hyperbilirubinemia
HP:0002910	Elevated hepatic transaminase
HP:0003146	Hypocholesterolemia
HP:0003256	Abnormality of the coagulation cascade
HP:0003623	Neonatal onset
HP:0006566	Neonatal cholestatic liver disease
HP:0009830	Peripheral neuropathy
HP:0011985	Acholic stools
HP:0200084	Giant cell hepatitis

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	High	Approved
caudate	glial cells	Medium	Approved
cerebral cortex	neuropil	Low	Approved
colon	glandular cells	High	Approved
duodenum	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	Low	Approved
esophagus	squamous epithelial cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	glial cells	Medium	Approved
kidney	cells in tubules	High	Approved
liver	hepatocytes	Medium	Approved
lung	macrophages	High	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	High	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	High	Approved
thyroid gland	glandular cells	Low	Approved