Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.4.12
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
DNA helicase.
3.6.4.13
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
RNA helicase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2N16 | Solution structure of G-quadruplex recognition domain of RHAU | |
| 2N21 | Solution structure of complex between DNA G-quadruplex and G-quadruplex recognition domain of RHAU | |
| 6Q6R | 1.5 | Recognition of different base tetrads by RHAU: X-ray crystal structure of G4 recognition motif bound to the 3-end tetrad of a DNA G-quadruplex |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| Biological Process | GO:0044806 | G-quadruplex DNA unwinding |
| Biological Process | GO:0010501 | RNA secondary structure unwinding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:1903843 | cellular response to arsenite ion |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| Biological Process | GO:0051891 | positive regulation of cardioblast differentiation |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1901534 | positive regulation of hematopoietic progenitor cell differentiation |
| Biological Process | GO:0032727 | positive regulation of interferon-alpha production |
| Biological Process | GO:1904582 | positive regulation of intracellular mRNA localization |
| Biological Process | GO:0031442 | positive regulation of mRNA 3'-end processing |
| Biological Process | GO:0002735 | positive regulation of myeloid dendritic cell cytokine production |
| Biological Process | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:0032206 | positive regulation of telomere maintenance |
| Biological Process | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0006359 | regulation of transcription by RNA polymerase III |
| Biological Process | GO:0043330 | response to exogenous dsRNA |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0090669 | telomerase RNA stabilization |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Molecular Function | GO:0003678 | DNA helicase activity |
| Molecular Function | GO:0051880 | G-quadruplex DNA binding |
| Molecular Function | GO:0002151 | G-quadruplex RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0048027 | mRNA 5'-UTR binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0070883 | pre-miRNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0070034 | telomerase RNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| InterPro
|
InterPro name |
|---|---|
| IPR001650 | Helicase, C-terminal |
| IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| IPR007502 | Helicase-associated domain |
| IPR011545 | DEAD/DEAH box helicase domain |
| IPR011709 | DEAD-box helicase, OB fold |
| IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Pfam
|
Pfam name |
|---|---|
| PF00270 | DEAD/DEAH box helicase |
| PF00271 | Helicase conserved C-terminal domain |
| PF04408 | Helicase associated domain (HA2) |
| PF07717 | Oligonucleotide/oligosaccharide-binding (OB)-fold |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell projection, axon | ECO:0000250 | |
| Cell projection, dendrite | ECO:0000250 | |
| Chromosome, telomere | ECO:0000269 | PubMed:20472641 |
| Cytoplasm | ECO:0000269 | PubMed:14731398 |
| Cytoplasm | ECO:0000269 | PubMed:18279852 |
| Cytoplasm | ECO:0000269 | PubMed:18854321 |
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:18854321 |
| Cytoplasm, cytosol | ECO:0000250 | |
| Mitochondrion | ECO:0000250 | |
| Nucleus | ECO:0000269 | PubMed:14731398 |
| Nucleus | ECO:0000269 | PubMed:18279852 |
| Nucleus | ECO:0000269 | PubMed:18854321 |
| Nucleus speckle | ECO:0000269 | PubMed:18279852 |
| Perikaryon | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | High | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | High | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | chondrocytes | High | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|