Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2KIU | Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0061470 | T follicular helper cell differentiation |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0042118 | endothelial cell activation |
| Biological Process | GO:0042116 | macrophage activation |
| Biological Process | GO:0042117 | monocyte activation |
| Biological Process | GO:0002903 | negative regulation of B cell apoptotic process |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0036035 | osteoclast development |
| Biological Process | GO:0030316 | osteoclast differentiation |
| Biological Process | GO:0050861 | positive regulation of B cell receptor signaling pathway |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:1905206 | positive regulation of hydrogen peroxide-induced cell death |
| Biological Process | GO:0032745 | positive regulation of interleukin-21 production |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:2000341 | regulation of chemokine (C-X-C motif) ligand 2 production |
| Biological Process | GO:1900424 | regulation of defense response to bacterium |
| Biological Process | GO:1901509 | regulation of endothelial tube morphogenesis |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0032651 | regulation of interleukin-1 beta production |
| Biological Process | GO:0032655 | regulation of interleukin-12 production |
| Biological Process | GO:1901256 | regulation of macrophage colony-stimulating factor production |
| Biological Process | GO:0045655 | regulation of monocyte differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032680 | regulation of tumor necrosis factor production |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0033574 | response to testosterone |
| Biological Process | GO:0021756 | striatum development |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0043621 | protein self-association |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR001766 | Fork head domain |
| IPR030456 | Fork head domain conserved site 2 |
| IPR032354 | FOXP, coiled-coil domain |
| IPR036388 | Winged helix-like DNA-binding domain superfamily |
| IPR036390 | Winged helix DNA-binding domain superfamily |
| IPR047412 | Forkhead box protein P1/P2, forkhead domain |
| Pfam
|
Pfam name |
|---|---|
| PF00250 | Forkhead domain |
| PF16159 | FOXP coiled-coil domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | Internal node | R-HSA-1266738 | Developmental Biology |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000269 | PubMed:25027557 |
| Nucleus | ECO:0000269 | PubMed:26647308 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000077 | Abnormality of the kidney |
| HP:0000119 | Abnormality of the genitourinary system |
| HP:0000194 | Open mouth |
| HP:0000256 | Macrocephaly |
| HP:0000272 | Malar flattening |
| HP:0000278 | Retrognathia |
| HP:0000303 | Mandibular prognathia |
| HP:0000316 | Hypertelorism |
| HP:0000403 | Recurrent otitis media |
| HP:0000455 | Broad nasal tip |
| HP:0000478 | Abnormality of the eye |
| HP:0000486 | Strabismus |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000505 | Visual impairment |
| HP:0000508 | Ptosis |
| HP:0000539 | Abnormality of refraction |
| HP:0000581 | Blepharophimosis |
| HP:0000598 | Abnormality of the ear |
| HP:0000614 | Abnormal nasolacrimal system morphology |
| HP:0000639 | Nystagmus |
| HP:0000708 | Atypical behavior |
| HP:0000718 | Aggressive behavior |
| HP:0000722 | Compulsive behaviors |
| HP:0000729 | Autistic behavior |
| HP:0000733 | Abnormal repetitive mannerisms |
| HP:0000736 | Short attention span |
| HP:0000739 | Anxiety |
| HP:0000750 | Delayed speech and language development |
| HP:0000805 | Enuresis |
| HP:0000819 | Diabetes mellitus |
| HP:0000820 | Abnormality of the thyroid gland |
| HP:0000821 | Hypothyroidism |
| HP:0000954 | Single transverse palmar crease |
| HP:0000975 | Hyperhidrosis |
| HP:0001212 | Prominent fingertip pads |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001256 | Intellectual disability, mild |
| HP:0001257 | Spasticity |
| HP:0001263 | Global developmental delay |
| HP:0001270 | Motor delay |
| HP:0001290 | Generalized hypotonia |
| HP:0001371 | Flexion contracture |
| HP:0001508 | Failure to thrive |
| HP:0001513 | Obesity |
| HP:0001531 | Failure to thrive in infancy |
| HP:0001581 | Recurrent skin infections |
| HP:0001627 | Abnormal heart morphology |
| HP:0001824 | Weight loss |
| HP:0001903 | Anemia |
| HP:0001945 | Fever |
| HP:0002017 | Nausea and vomiting |
| HP:0002019 | Constipation |
| HP:0002027 | Abdominal pain |
| HP:0002092 | Pulmonary arterial hypertension |
| HP:0002113 | Pulmonary infiltrates |
| HP:0002188 | Delayed CNS myelination |
| HP:0002194 | Delayed gross motor development |
| HP:0002205 | Recurrent respiratory infections |
| HP:0002236 | Frontal upsweep of hair |
| HP:0002307 | Drooling |
| HP:0002342 | Intellectual disability, moderate |
| HP:0002353 | EEG abnormality |
| HP:0002463 | Language impairment |
| HP:0002474 | Expressive language delay |
| HP:0002714 | Downturned corners of mouth |
| HP:0002716 | Lymphadenopathy |
| HP:0002788 | Recurrent upper respiratory tract infections |
| HP:0003196 | Short nose |
| HP:0003593 | Infantile onset |
| HP:0005272 | Prominent nasolabial fold |
| HP:0007018 | Attention deficit hyperactivity disorder |
| HP:0007301 | Oromotor apraxia |
| HP:0008589 | Hypoplastic helices |
| HP:0008762 | Repetitive compulsive behavior |
| HP:0008872 | Feeding difficulties in infancy |
| HP:0009088 | Speech articulation difficulties |
| HP:0010864 | Intellectual disability, severe |
| HP:0011098 | Speech apraxia |
| HP:0011220 | Prominent forehead |
| HP:0011298 | Prominent digit pad |
| HP:0011823 | Chin with horizontal crease |
| HP:0011968 | Feeding difficulties |
| HP:0012123 | Posterior uveitis |
| HP:0012191 | B-cell lymphoma |
| HP:0012378 | Fatigue |
| HP:0012393 | Allergy |
| HP:0012471 | Thick vermilion border |
| HP:0025502 | Overweight |
| HP:0030084 | Clinodactyly |
| HP:0031936 | Delayed ability to walk |
| HP:0040303 | Decreased serum iron |
| HP:0100716 | Self-injurious behavior |
| HP:0100721 | Mediastinal lymphadenopathy |
| HP:0410263 | Brain imaging abnormality |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Low | Supported |
| appendix | endocrine cells | High | Supported |
| appendix | enterocytes | High | Supported |
| appendix | germinal center cells | Medium | Supported |
| appendix | goblet cells | High | Supported |
| appendix | non-germinal center cells | High | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | adipocytes | Low | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | High | Supported |
| caudate | neuronal cells | High | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | Low | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endocrine cells | High | Supported |
| colon | endothelial cells | High | Supported |
| colon | enterocytes | High | Supported |
| colon | fibroblasts | High | Supported |
| colon | goblet cells | High | Supported |
| colon | mucosal lymphoid cells | Medium | Supported |
| duodenum | endocrine cells | High | Supported |
| duodenum | enterocytes | High | Supported |
| duodenum | goblet cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Low | Supported |
| endometrium 1 | glandular cells | Low | Supported |
| endometrium 2 | cells in endometrial stroma | Low | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | Medium | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | neuronal cells | Low | Supported |
| kidney | cells in glomeruli | Low | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | alveolar cells type II | Medium | Supported |
| lung | endothelial cells | High | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Low | Supported |
| lymph node | non-germinal center cells | High | Supported |
| nasopharynx | respiratory epithelial cells | High | Supported |
| oral mucosa | squamous epithelial cells | High | Supported |
| ovary | follicle cells | Low | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | Medium | Supported |
| pancreas | pancreatic endocrine cells | Low | Supported |
| parathyroid gland | glandular cells | Medium | Supported |
| placenta | decidual cells | Low | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | endocrine cells | High | Supported |
| rectum | endothelial cells | High | Supported |
| rectum | enterocytes | High | Supported |
| rectum | fibroblasts | High | Supported |
| rectum | goblet cells | High | Supported |
| rectum | mucosal lymphoid cells | Medium | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | Low | Supported |
| skeletal muscle | myocytes | High | Supported |
| skin 1 | cells in basal layer | Low | Supported |
| skin 1 | cells in granular layer | Low | Supported |
| skin 1 | cells in spinous layer | Low | Supported |
| skin 1 | endothelial cells | High | Supported |
| skin 1 | fibrohistiocytic cells | High | Supported |
| skin 1 | langerhans cells | Low | Supported |
| skin 1 | lymphocytes | High | Supported |
| skin 1 | melanocytes | Low | Supported |
| skin 2 | arrector pili muscle cells | High | Supported |
| skin 2 | cells in basal layer | Medium | Supported |
| skin 2 | cells in granular layer | Low | Supported |
| skin 2 | cells in spinous layer | Low | Supported |
| skin 2 | endothelial cells | High | Supported |
| skin 2 | fibrohistiocytic cells | High | Supported |
| skin 2 | hair follicles | Low | Supported |
| skin 2 | langerhans cells | Low | Supported |
| skin 2 | lymphocytes | High | Supported |
| small intestine | endocrine cells | Medium | Supported |
| small intestine | enterocytes | Medium | Supported |
| small intestine | goblet cells | Medium | Supported |
| small intestine | paneth cells | High | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | High | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | sertoli cells | Low | Supported |
| testis | spermatogonia cells | Low | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | High | Supported |
| tonsil | squamous epithelial cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| strabismus | MONDO:0003432 | H50 | chapter7, Diseases of the eye and adnexa | ||
| intellectual disability-severe speech delay-mild dysmorphism syndrome | MONDO:0013352 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:613670 | Orphanet:391372 |