MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q9H6Z9

Gene: EGLN3
Protein: Prolyl hydroxylase EGLN3

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
1.14.11.-	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
1.14.11.29	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor; hypoxia-inducible factor-proline dioxygenase

Publications

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process	GO:0018126	protein hydroxylation
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0043523	regulation of neuron apoptotic process
Biological Process	GO:0001666	response to hypoxia
Molecular Function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity
Molecular Function	GO:0031418	L-ascorbic acid binding
Molecular Function	GO:0008198	ferrous iron binding
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease