Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.1.259
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
N-terminal methionine Nα-acetyltransferase NatF
2.3.1.48
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
histone acetyltransferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 5HGZ | 1.383 | Crystal structure of human Naa60 in complex with acetyl-CoA |
| 5HH0 | 1.6 | Crystal structure of human Naa60 in complex with CoA |
| 5HH1 | 1.803 | Crystal structure of human Naa60 mutant - F34A in complex with CoA |
| 5ICV | 1.53 | Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue |
| 5ICW | 1.951 | Crystal structure of human NatF (hNaa60) homodimer bound to Coenzyme A |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0017196 | N-terminal peptidyl-methionine acetylation |
| Biological Process | GO:0006474 | N-terminal protein amino acid acetylation |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0043966 | histone H3 acetylation |
| Biological Process | GO:0006334 | nucleosome assembly |
| Molecular Function | GO:0010485 | histone H4 acetyltransferase activity |
| Molecular Function | GO:0004402 | histone acetyltransferase activity |
| Molecular Function | GO:0004596 | peptide alpha-N-acetyltransferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Cellular Component | GO:0000139 | Golgi membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Golgi apparatus membrane | ECO:0000269 | PubMed:21981917 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:25732826 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | High | Approved |
| cervix | glandular cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | macrophages | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | chondrocytes | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | Low | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|