MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.-.-	Hydrolases; Acting on ester bonds; ;
3.5.2.6	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amides; β-lactamase

PDB	Resolution (Å)	PDB name
3BUA	2.5	Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex
5AHO	2.16	Crystal structure of human 5' exonuclease Apollo
7A1F	1.8	Crystal structure of human 5' exonuclease Appollo in complex with 5'dAMP
7B2X	3.1	Crystal structure of human 5' exonuclease Appollo H61Y variant
7B9B	2.8	Crystal structure of human 5' exonuclease Appollo APO form

GO ontology	GO term	GO description
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining
Biological Process	GO:0036297	interstrand cross-link repair
Biological Process	GO:0031848	protection from non-homologous end joining at telomere
Biological Process	GO:0016233	telomere capping
Biological Process	GO:0000723	telomere maintenance
Biological Process	GO:0010833	telomere maintenance via telomere lengthening
Biological Process	GO:0031860	telomeric 3' overhang formation
Biological Process	GO:0031627	telomeric loop formation
Molecular Function	GO:0035312	5'-3' DNA exonuclease activity
Molecular Function	GO:0008409	5'-3' exonuclease activity
Molecular Function	GO:0008800	beta-lactamase activity
Molecular Function	GO:0003684	damaged DNA binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0044877	protein-containing complex binding
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm

InterPro	InterPro name
IPR011084	DNA repair metallo-beta-lactamase
IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Location	ECO term	Pubmed
Chromosome, telomere
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Nucleus

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000601	Hypotelorism
HP:0000750	Delayed speech and language development
HP:0000967	Petechiae
HP:0001272	Cerebellar atrophy
HP:0001511	Intrauterine growth retardation
HP:0001622	Premature birth
HP:0001876	Pancytopenia
HP:0002037	Inflammation of the large intestine
HP:0002043	Esophageal stricture
HP:0002209	Sparse scalp hair
HP:0002721	Immunodeficiency
HP:0002745	Oral leukoplakia
HP:0003221	Chromosomal breakage induced by crosslinking agents
HP:0003593	Infantile onset
HP:0003621	Juvenile onset
HP:0005528	Bone marrow hypocellularity
HP:0008404	Nail dystrophy
HP:0010976	B lymphocytopenia
HP:0033256	Pancolitis
HP:0040218	Reduced natural killer cell count