Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.1.-
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
3.1.1.5
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
lysophospholipase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019369 | arachidonic acid metabolic process |
| Biological Process | GO:0050482 | arachidonic acid secretion |
| Biological Process | GO:0032048 | cardiolipin metabolic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0055088 | lipid homeostasis |
| Biological Process | GO:0034638 | phosphatidylcholine catabolic process |
| Biological Process | GO:0046338 | phosphatidylethanolamine catabolic process |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:1900407 | regulation of cellular response to oxidative stress |
| Biological Process | GO:0070328 | triglyceride homeostasis |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047499 | calcium-independent phospholipase A2 activity |
| Molecular Function | GO:0004622 | lysophospholipase activity |
| Molecular Function | GO:0102545 | phosphatidyl phospholipase B activity |
| Molecular Function | GO:0008970 | phospholipase A1 activity |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1482788 | Acyl chain remodelling of PC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482839 | Acyl chain remodelling of PE | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum membrane | ECO:0000250 | PubMed:10744668 |
| Endoplasmic reticulum membrane | ECO:0000250 | PubMed:10833412 |
| Mitochondrion membrane | ECO:0000305 | PubMed:10744668 |
| Mitochondrion membrane | ECO:0000305 | PubMed:10833412 |
| Mitochondrion membrane | ECO:0000305 | PubMed:17213206 |
| Peroxisome membrane | ECO:0000269 | PubMed:10744668 |
| Peroxisome membrane | ECO:0000269 | PubMed:10833412 |
| Peroxisome membrane | ECO:0000269 | PubMed:15695510 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001257 | Spasticity |
| HP:0001260 | Dysarthria |
| HP:0001310 | Dysmetria |
| HP:0001332 | Dystonia |
| HP:0002151 | Increased serum lactate |
| HP:0002384 | Focal impaired awareness seizure |
| HP:0003128 | Lactic acidosis |
| HP:0003391 | Gowers sign |
| HP:0003542 | Increased serum pyruvate |
| HP:0003676 | Progressive |
| HP:0003701 | Proximal muscle weakness |
| HP:0003737 | Mitochondrial myopathy |
| HP:0011463 | Childhood onset |
| HP:0012378 | Fatigue |
| HP:0012446 | Decreased CSF 5-methyltetrahydrofolate concentration |
| HP:0030051 | Tip-toe gait |
| HP:0031962 | Elevated serum anion gap |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | High | Approved |
| cerebellum | cells in molecular layer | High | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | High | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | High | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | High | Approved |
| ovary | ovarian stroma cells | Medium | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | High | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | High | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| mitochondrial myopathy-lactic acidosis-deafness syndrome | MONDO:0016825 | G71 | chapter6, Diseases of the nervous system | OMIM:251950 | Orphanet:2597 |