MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.1.1.-	Transferases; Transferring one-carbon groups; Methyltransferases;
2.1.1.361	Transferases; Transferring one-carbon groups; Methyltransferases; [histone H4]-lysine20 N-methyltransferase

PDB	Resolution (Å)	PDB name
1ZKK	1.45	Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy
2BQZ	1.5	Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
3F9W	1.6	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy
3F9X	1.25	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy
3F9Y	1.5	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy
3F9Z	1.6	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy
4IJ8	2.0	Crystal structure of the complex of SETD8 with SAM
5HQ2	4.5	Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle
5T5G	2.1	human SETD8 in complex with MS2177
5TEG	1.3	Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine
5TH7	1.95	Complex of SETD8 with MS453
5V2N	2.0	Crystal Structure of APO Human SETD8
5W1Y	1.7	SETD8 in complex with a covalent inhibitor
6BOZ	2.4	Structure of human SETD8 in complex with covalent inhibitor MS4138
7D1Z	3.15	Cryo-EM structure of SET8-nucleosome complex
7D20	3.0	Cryo-EM structure of SET8-CENP-A-nucleosome complex
7XPX	3.2	Cryo-EM structure of the histone methyltransferase SET8 bound to H4K20Ecx-nucleosome

GO ontology	GO term	GO description
Biological Process	GO:0051301	cell division
Biological Process	GO:0007076	mitotic chromosome condensation
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0018026	peptidyl-lysine monomethylation
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process	GO:1901796	regulation of signal transduction by p53 class mediator
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Molecular Function	GO:0042799	histone H4K20 methyltransferase activity
Molecular Function	GO:0140944	histone H4K20 monomethyltransferase activity
Molecular Function	GO:0042054	histone methyltransferase activity
Molecular Function	GO:0016278	lysine N-methyltransferase activity
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity
Molecular Function	GO:0003714	transcription corepressor activity
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005700	polytene chromosome

InterPro	InterPro name
IPR001214	SET domain
IPR016858	N-lysine methyltransferase KMT5A-like
IPR046341	SET domain superfamily
IPR047266	N-lysine methyltransferase KMT5A-like, SET domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2299718	Condensation of Prophase Chromosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3214841	PKMTs methylate histone lysines	Leaf	R-HSA-4839726	Chromatin organization
R-HSA-6804760	Regulation of TP53 Activity through Methylation	Leaf	R-HSA-74160	Gene expression (Transcription)