MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.11.1.-	Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases;
1.6.3.1	Oxidoreductases; Acting on NADH or NADPH; With oxygen as acceptor; NAD(P)H oxidase (H2O2-forming)

PDB	Resolution (Å)	PDB name
7D3E	2.8	Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state
7D3F	2.6	Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state

GO ontology	GO term	GO description
Biological Process	GO:0042335	cuticle development
Biological Process	GO:0019221	cytokine-mediated signaling pathway
Biological Process	GO:0006952	defense response
Biological Process	GO:0042446	hormone biosynthetic process
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process
Biological Process	GO:0042744	hydrogen peroxide catabolic process
Biological Process	GO:2000147	positive regulation of cell motility
Biological Process	GO:0090303	positive regulation of wound healing
Biological Process	GO:0051591	response to cAMP
Biological Process	GO:0006979	response to oxidative stress
Biological Process	GO:0042554	superoxide anion generation
Biological Process	GO:0006590	thyroid hormone generation
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity
Molecular Function	GO:0106293	NADH oxidase H202-forming activity
Molecular Function	GO:0050661	NADP binding
Molecular Function	GO:0106294	NADPH oxidase H202-forming activity
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0004601	peroxidase activity
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity
Cellular Component	GO:0043020	NADPH oxidase complex
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR002048	EF-hand domain
IPR010255	Haem peroxidase superfamily
IPR011992	EF-hand domain pair
IPR013112	FAD-binding 8
IPR013121	Ferric reductase, NAD binding domain
IPR013130	Ferric reductase transmembrane component-like domain
IPR017927	FAD-binding domain, ferredoxin reductase-type
IPR017938	Riboflavin synthase-like beta-barrel
IPR018247	EF-Hand 1, calcium-binding site
IPR019791	Haem peroxidase, animal-type
IPR034821	Dual oxidase, peroxidase domain
IPR037120	Haem peroxidase domain superfamily, animal type
IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

Pfam	Pfam name
PF00036	EF hand
PF01794	Ferric reductase like transmembrane component
PF03098	Animal haem peroxidase
PF08022	FAD-binding domain
PF08030	Ferric reductase NAD binding domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-209968	Thyroxine biosynthesis	Internal node	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Apical cell membrane	ECO:0000269	PubMed:10806195
Apical cell membrane	ECO:0000269	PubMed:15210697

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Low	Approved
bronchus	respiratory epithelial cells	Low	Approved
duodenum	glandular cells	Low	Approved
endometrium 1	glandular cells	Low	Approved
epididymis	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
lung	macrophages	Low	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
rectum	glandular cells	Medium	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	cells in seminiferous ducts	Low	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved