MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.3.16	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; protein-serine/threonine phosphatase
3.1.3.48	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; protein-tyrosine-phosphatase

Structure

PDB	Resolution (Å)	PDB name
1WRM	1.5	Crystal structure of JSP-1
4WOH	1.34	Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate
6L1S	1.3611	Crystal structure of DUSP22 mutant_C88S
6LMY	1.5	Crystal structure of DUSP22 mutant_C88S/S93A
6LOT	1.69	Crystal structure of DUSP22 mutant_N128D
6LOU	1.5301	Crystal structure of DUSP22 mutant_C88S/S93N
6LVQ	1.38	Crystal structure of DUSP22_VO4
7C8S	1.31	Crystal structure of DUSP22 mutant_N128A

GO term

GO ontology	GO term	GO description
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus
Biological Process	GO:0016311	dephosphorylation
Biological Process	GO:0050868	negative regulation of T cell activation
Biological Process	GO:0002710	negative regulation of T cell mediated immunity
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0051895	negative regulation of focal adhesion assembly
Biological Process	GO:1903996	negative regulation of non-membrane spanning protein tyrosine kinase activity
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
Molecular Function	GO:0017018	myosin phosphatase activity
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
Molecular Function	GO:1990782	protein tyrosine kinase binding
Molecular Function	GO:0004725	protein tyrosine phosphatase activity
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0061851	leading edge of lamellipodium
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine-specific protein phosphatases domain
IPR020422	Dual specificity protein phosphatase domain
IPR029021	Protein-tyrosine phosphatase-like

Pfam	Pfam name
PF00782	Dual specificity phosphatase, catalytic domain

Reactome

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:20553486

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	Low	Approved
appendix	lymphoid tissue	Low	Approved
bone marrow	hematopoietic cells	High	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	High	Approved
cerebellum	cells in granular layer	Low	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	High	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	High	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	High	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	High	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in glomeruli	Low	Approved
kidney	cells in tubules	High	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	Low	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	High	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	follicle cells	Medium	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	High	Approved
placenta	decidual cells	High	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	High	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Medium	Approved
skin 1	fibroblasts	High	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	High	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Medium	Approved
soft tissue 1	chondrocytes	Medium	Approved
soft tissue 1	fibroblasts	High	Approved
soft tissue 1	peripheral nerve	Low	Approved
soft tissue 2	chondrocytes	Medium	Approved
soft tissue 2	fibroblasts	Medium	Approved
soft tissue 2	peripheral nerve	Low	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	High	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	elongated or late spermatids	Medium	Approved
testis	pachytene spermatocytes	Medium	Approved
testis	peritubular cells	High	Approved
testis	preleptotene spermatocytes	High	Approved
testis	round or early spermatids	Medium	Approved
testis	sertoli cells	Low	Approved
testis	spermatogonia cells	High	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Low	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	High	Approved

Disease

Summary of Q9NRW4

Gene: DUSP22, JSP1, LMWDSP2, MKPX
Protein: Dual specificity protein phosphatase 22

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9NRW4

Gene: DUSP22, JSP1, LMWDSP2, MKPX Protein: Dual specificity protein phosphatase 22

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: DUSP22, JSP1, LMWDSP2, MKPX
Protein: Dual specificity protein phosphatase 22