MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
5VAQ	2.606	Crystal Structure of Beta-Klotho in Complex with FGF21CT
6M6E		Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
6M6F		Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0071377	cellular response to glucagon stimulus
Biological Process	GO:0071333	cellular response to glucose stimulus
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus
Biological Process	GO:0071466	cellular response to xenobiotic stimulus
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response
Biological Process	GO:0072577	endothelial cell apoptotic process
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process
Biological Process	GO:1901215	negative regulation of neuron death
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0046326	positive regulation of glucose import
Biological Process	GO:1905599	positive regulation of low-density lipoprotein receptor activity
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:0010988	regulation of low-density lipoprotein particle clearance
Biological Process	GO:0014823	response to activity
Biological Process	GO:1904640	response to methionine
Biological Process	GO:0031667	response to nutrient levels
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0005104	fibroblast growth factor receptor binding
Molecular Function	GO:0008083	growth factor activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR035444	Fibroblast growth factor 15/19/21

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-189200	Cellular hexose transport	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	Leaf	R-HSA-382551	Transport of small molecules

Summary of Q9NSA1

Gene: FGF21, UNQ3115/PRO10196
Protein: Fibroblast growth factor 21

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9NSA1

Gene: FGF21, UNQ3115/PRO10196 Protein: Fibroblast growth factor 21

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: FGF21, UNQ3115/PRO10196
Protein: Fibroblast growth factor 21