Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.2.1.1
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
acetate—CoA ligase
6.2.1.17
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
propionate—CoA ligase
PDB | Resolution (Å) | PDB name |
---|---|---|
3GLR | 1.8 | Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide |
3GLT | 2.1 | Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine |
3GLU | 2.5 | Crystal Structure of Human SIRT3 with AceCS2 peptide |
4BVE | 2.05 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE |
4BVF | 2.7 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 |
4BVG | 2.5 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 |
4C78 | 2.0 | Complex of human Sirt3 with Bromo-Resveratrol and ACS2 peptide |
5Y4H | 2.6 | Human SIRT3 in complex with halistanol sulfate |
5YTK | 2.7 | Crystal structure of SIRT3 bound to a leucylated AceCS2 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0019413 | acetate biosynthetic process |
Biological Process | GO:0006085 | acetyl-CoA biosynthetic process |
Biological Process | GO:0019427 | acetyl-CoA biosynthetic process from acetate |
Biological Process | GO:0006069 | ethanol oxidation |
Biological Process | GO:0019542 | propionate biosynthetic process |
Molecular Function | GO:0016208 | AMP binding |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0003987 | acetate-CoA ligase activity |
Molecular Function | GO:0050218 | propionate-CoA ligase activity |
Cellular Component | GO:0005759 | mitochondrial matrix |
Cellular Component | GO:0005739 | mitochondrion |
InterPro | InterPro name |
---|---|
IPR000873 | AMP-dependent synthetase/ligase domain |
IPR011904 | Acetate-CoA ligase |
IPR020845 | AMP-binding, conserved site |
IPR025110 | AMP-binding enzyme, C-terminal domain |
IPR032387 | Acetyl-coenzyme A synthetase, N-terminal domain |
IPR042099 | ANL, N-terminal domain |
IPR045851 | AMP-binding enzyme, C-terminal domain superfamily |
Pfam | Pfam name |
---|---|
PF00501 | AMP-binding enzyme |
PF13193 | AMP-binding enzyme C-terminal domain |
PF16177 | Acetyl-coenzyme A synthetase N-terminus |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-71384 | Ethanol oxidation | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Mitochondrion matrix | ECO:0000269 | PubMed:16788062 |