Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.2.1.1
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
acetate—CoA ligase
6.2.1.17
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
propionate—CoA ligase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3GLR | 1.8 | Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide |
| 3GLT | 2.1 | Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine |
| 3GLU | 2.5 | Crystal Structure of Human SIRT3 with AceCS2 peptide |
| 4BVE | 2.05 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE |
| 4BVF | 2.7 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 |
| 4BVG | 2.5 | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 |
| 4C78 | 2.0 | Complex of human Sirt3 with Bromo-Resveratrol and ACS2 peptide |
| 5Y4H | 2.6 | Human SIRT3 in complex with halistanol sulfate |
| 5YTK | 2.7 | Crystal structure of SIRT3 bound to a leucylated AceCS2 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019413 | acetate biosynthetic process |
| Biological Process | GO:0006085 | acetyl-CoA biosynthetic process |
| Biological Process | GO:0019427 | acetyl-CoA biosynthetic process from acetate |
| Biological Process | GO:0006069 | ethanol oxidation |
| Biological Process | GO:0019542 | propionate biosynthetic process |
| Molecular Function | GO:0016208 | AMP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003987 | acetate-CoA ligase activity |
| Molecular Function | GO:0050218 | propionate-CoA ligase activity |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| InterPro
|
InterPro name |
|---|---|
| IPR000873 | AMP-dependent synthetase/ligase domain |
| IPR011904 | Acetate-CoA ligase |
| IPR020845 | AMP-binding, conserved site |
| IPR025110 | AMP-binding enzyme, C-terminal domain |
| IPR032387 | Acetyl-coenzyme A synthetase, N-terminal domain |
| IPR042099 | ANL, N-terminal domain |
| IPR045851 | AMP-binding enzyme, C-terminal domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00501 | AMP-binding enzyme |
| PF13193 | AMP-binding enzyme C-terminal domain |
| PF16177 | Acetyl-coenzyme A synthetase N-terminus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-71384 | Ethanol oxidation | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion matrix | ECO:0000269 | PubMed:16788062 |