MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.5.1.-	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides;
3.5.1.23	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides; ceramidase

PDB	Resolution (Å)	PDB name
6G7O	2.7	Crystal structure of human alkaline ceramidase 3 (ACER3) at 2.7 Angstrom resolution
6YXH	2.6	Cryogenic human alkaline ceramidase 3 (ACER3) at 2.6 A resolution determined by Serial Crystallography (SSX) using CrystalDirect

GO ontology	GO term	GO description
Biological Process	GO:0046514	ceramide catabolic process
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0042552	myelination
Biological Process	GO:0071602	phytosphingosine biosynthetic process
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0043067	regulation of programmed cell death
Biological Process	GO:0030148	sphingolipid biosynthetic process
Biological Process	GO:0046512	sphingosine biosynthetic process
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0102121	ceramidase activity
Molecular Function	GO:0071633	dihydroceramidase activity
Molecular Function	GO:0070774	phytoceramidase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane

InterPro	InterPro name
IPR008901	Alkaline ceramidase

Pfam	Pfam name
PF05875	Ceramidase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1660661	Sphingolipid de novo biosynthesis	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Endoplasmic reticulum membrane	ECO:0000269	PubMed:11356846
Endoplasmic reticulum membrane	ECO:0000269	PubMed:30575723
Golgi apparatus membrane	ECO:0000269	PubMed:11356846
Golgi apparatus membrane	ECO:0000269	PubMed:30575723

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000011	Neurogenic bladder
HP:0000179	Thick lower lip vermilion
HP:0000280	Coarse facial features
HP:0000319	Smooth philtrum
HP:0000340	Sloping forehead
HP:0000369	Low-set ears
HP:0000448	Prominent nose
HP:0000543	Optic disc pallor
HP:0000574	Thick eyebrow
HP:0001284	Areflexia
HP:0001332	Dystonia
HP:0002059	Cerebral atrophy
HP:0002079	Hypoplasia of the corpus callosum
HP:0002376	Developmental regression
HP:0002415	Leukodystrophy
HP:0003593	Infantile onset
HP:0003676	Progressive
HP:0004322	Short stature
HP:0004482	Relative macrocephaly
HP:0007281	Developmental stagnation
HP:0008936	Axial hypotonia
HP:0009830	Peripheral neuropathy
HP:0010864	Intellectual disability, severe
HP:0034353	Appendicular spasticity
HP:0034392	Joint contracture

Tissue	Cell type	Expression level	Reliability
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
bronchus	ciliated cells (ciliary rootlets)	Low	Approved
colon	endothelial cells	High	Approved
colon	peripheral nerve/ganglion	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
fallopian tube	ciliated cells (cell body)	Medium	Approved
kidney	cells in glomeruli	High	Approved
kidney	cells in tubules	Medium	Approved
lung	macrophages	High	Approved
nasopharynx	ciliated cells (cell body)	Low	Approved
ovary	follicle cells	Medium	Approved
ovary	ovarian stroma cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
placenta	decidual cells	High	Approved
seminal vesicle	glandular cells	Medium	Approved
skin 1	Langerhans	Medium	Approved
skin 1	fibroblasts	High	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	High	Approved
skin 2	epidermal cells	Medium	Approved
soft tissue 2	peripheral nerve	High	Approved
testis	Leydig cells	Medium	Approved
testis	sertoli cells	High	Approved