Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.1.1.-
Transferases;
Transferring one-carbon groups;
Methyltransferases;
2.1.1.364
Transferases;
Transferring one-carbon groups;
Methyltransferases;
[histone H3]-lysine4 N-methyltransferase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0018027 | peptidyl-lysine dimethylation |
| Biological Process | GO:0018026 | peptidyl-lysine monomethylation |
| Biological Process | GO:0018023 | peptidyl-lysine trimethylation |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0071863 | regulation of cell proliferation in bone marrow |
| Molecular Function | GO:0046975 | histone H3K36 methyltransferase activity |
| Molecular Function | GO:0042800 | histone H3K4 methyltransferase activity |
| Molecular Function | GO:0140945 | histone H3K4 monomethyltransferase activity |
| Molecular Function | GO:0042799 | histone H4K20 methyltransferase activity |
| Molecular Function | GO:0140944 | histone H4K20 monomethyltransferase activity |
| Molecular Function | GO:0140941 | histone H4K20me methyltransferase activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR001214 | SET domain |
| IPR015353 | Rubisco LSMT, substrate-binding domain |
| IPR016852 | SET domain methyltransferase |
| IPR036464 | Rubisco LSMT, substrate-binding domain superfamily |
| IPR044429 | SETD4, SET domain |
| IPR046341 | SET domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00856 | SET domain |
| PF09273 | Rubisco LSMT substrate-binding |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:24738023 |
| Nucleus | ECO:0000269 | PubMed:24738023 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | basal cells | Medium | Approved |
| bronchus | ciliated cells (cell body) | High | Approved |
| bronchus | ciliated cells (cilia axoneme) | Medium | Approved |
| bronchus | ciliated cells (ciliary rootlets) | Medium | Approved |
| bronchus | ciliated cells (tip of cilia) | Medium | Approved |
| bronchus | goblet cells | High | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | ciliated cells (cell body) | High | Approved |
| fallopian tube | ciliated cells (ciliary rootlets) | High | Approved |
| fallopian tube | ciliated cells (tip of cilia) | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells type II | Medium | Approved |
| lung | macrophages | Low | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | basal cells | Medium | Approved |
| nasopharynx | ciliated cells (cell body) | Medium | Approved |
| nasopharynx | goblet cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| placenta | decidual cells | Low | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|