Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.22
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
cyclin-dependent kinase
2.7.11.23
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
[RNA-polymerase]-subunit kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
4CXA | 3.15 | Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP |
4NST | 2.2 | Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride |
4UN0 | 3.15 | Crystal structure of the human CDK12-cyclinK complex |
5ACB | 2.7 | Crystal Structure of the Human Cdk12-Cyclink Complex |
6B3E | 3.06 | Crystal structure of human CDK12/CyclinK in complex with an inhibitor |
6CKX | 2.8 | Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide |
6TD3 | 3.46 | Structure of DDB1 bound to CR8-engaged CDK12-cyclinK |
7NXK | 3.0 | Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0008380 | RNA splicing |
Biological Process | GO:0006397 | mRNA processing |
Biological Process | GO:2000737 | negative regulation of stem cell differentiation |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
Biological Process | GO:0046777 | protein autophosphorylation |
Biological Process | GO:0043405 | regulation of MAP kinase activity |
Biological Process | GO:0043484 | regulation of RNA splicing |
Biological Process | GO:0006366 | transcription by RNA polymerase II |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
Molecular Function | GO:0030332 | cyclin binding |
Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
Molecular Function | GO:0004672 | protein kinase activity |
Molecular Function | GO:0019901 | protein kinase binding |
Molecular Function | GO:0106310 | protein serine kinase activity |
Cellular Component | GO:0002944 | cyclin K-CDK12 complex |
Cellular Component | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
Cellular Component | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex |
Cellular Component | GO:0016607 | nuclear speck |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
Location | ECO term | Pubmed |
---|---|---|
Nucleus | ECO:0000269 | PubMed:11683387 |
Nucleus speckle | ECO:0000269 | PubMed:11683387 |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
lung adenocarcinoma | MONDO:0005061 | C34 | chapter2, Neoplasms | Orphanet:415268 |