Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 5MPF | 2.918 | Structural Basis of Gene Regulation by the Grainyhead Transcription Factor Superfamily |
| 5MPH | 2.337 | Structural Basis of Gene Regulation by the Grainyhead Transcription Factor Superfamily |
| 5MPI | 2.345 | Structural Basis of Gene Regulation by the Grainyhead Transcription Factor Superfamily |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0002934 | desmosome organization |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0061436 | establishment of skin barrier |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045616 | regulation of keratinocyte differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1989781 | PPARA activates gene expression | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000269 | PubMed:18288204 |
| Nucleus | ECO:0000269 | PubMed:35013237 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Enhanced |
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | adipocytes | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Low | Enhanced |
| caudate | neuronal cells | High | Enhanced |
| cerebral cortex | neuronal cells | High | Enhanced |
| cerebral cortex | neuropil | Low | Enhanced |
| cervix | squamous epithelial cells | High | Enhanced |
| colon | endothelial cells | High | Enhanced |
| duodenum | glandular cells | Low | Enhanced |
| endometrium 1 | cells in endometrial stroma | Low | Enhanced |
| esophagus | squamous epithelial cells | High | Enhanced |
| gallbladder | glandular cells | Low | Enhanced |
| heart muscle | cardiomyocytes | High | Enhanced |
| hippocampus | neuronal cells | High | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells | Medium | Enhanced |
| lung | macrophages | Low | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Low | Enhanced |
| oral mucosa | squamous epithelial cells | High | Enhanced |
| ovary | ovarian stroma cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | High | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Low | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | fibroblasts | High | Enhanced |
| skin 1 | keratinocytes | Medium | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Low | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Low | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | High | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | High | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|