Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1J3T | Solution structure of the second SH3 domain of human intersectin 2 (KIAA1256) | |
| 1UDL | The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256) | |
| 1UE9 | Solution structure of the fourth SH3 domain of human intersectin 2 (KIAA1256) | |
| 1UFF | Solution structure of the first SH3 domain of human intersectin2 (KIAA1256) | |
| 1UHF | Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256) | |
| 3GF9 | 2.5 | Crystal structure of human Intersectin 2 RhoGEF domain |
| 3JZY | 1.56 | Crystal structure of human Intersectin 2 C2 domain |
| 4IIO | 1.7 | Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0150007 | clathrin-dependent synaptic vesicle endocytosis |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0097708 | intracellular vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000008 | C2 domain |
| IPR000219 | Dbl homology (DH) domain |
| IPR000261 | EH domain |
| IPR001452 | SH3 domain |
| IPR001849 | Pleckstrin homology domain |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR011993 | PH-like domain superfamily |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR035737 | Intersectin-2, first SH3 domain |
| IPR035738 | Intersectin-2, second SH3 domain |
| IPR035739 | Intersectin-2, third SH3 domain |
| IPR035740 | Intersectin-2, fourth SH3 domain |
| IPR035741 | Intersectin-2, fifth SH3 domain |
| IPR035892 | C2 domain superfamily |
| IPR035899 | Dbl homology (DH) domain superfamily |
| IPR036028 | SH3-like domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00018 | SH3 domain |
| PF00168 | C2 domain |
| PF00621 | RhoGEF domain |
| PF07653 | Variant SH3 domain |
| PF12763 | Cytoskeletal-regulatory complex EF hand |
| PF14604 | Variant SH3 domain |
| PF16652 | Pleckstrin homology domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-8856828 | Clathrin-mediated endocytosis | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-9013420 | RHOU GTPase cycle | Leaf | R-HSA-162582 | Signal Transduction |