MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q9P0L2

Gene: MARK1, KIAA1477, MARK
Protein: Serine/threonine-protein kinase MARK1

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
2.7.11.1	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; non-specific serine/threonine protein kinase
2.7.11.26	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; tau-protein kinase

Publications

Structure

PDB	Resolution (Å)	PDB name
2HAK	2.6	Catalytic and ubiqutin-associated domains of MARK1/PAR-1
3OSE	1.7	Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase
6C9D	2.499	Crystal structure of KA1-autoinhibited MARK1 kinase

GO term

GO ontology	GO term	GO description
Biological Process	GO:0016055	Wnt signaling pathway
Biological Process	GO:0007010	cytoskeleton organization
Biological Process	GO:0051654	establishment of mitochondrion localization
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0001764	neuron migration
Biological Process	GO:0018105	peptidyl-serine phosphorylation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0050773	regulation of dendrite development
Biological Process	GO:0010975	regulation of neuron projection development
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0070300	phosphatidic acid binding
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
Molecular Function	GO:0001786	phosphatidylserine binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0048156	tau protein binding
Molecular Function	GO:0050321	tau-protein kinase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR001772	Kinase associated domain 1 (KA1)
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR015940	Ubiquitin-associated domain
IPR017441	Protein kinase, ATP binding site
IPR028375	KA1 domain/Ssp2, C-terminal

Pfam	Pfam name
PF00069	Protein kinase domain
PF00627	UBA/TS-N domain
PF02149	Kinase associated domain 1

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:21145462
Cell projection, dendrite	ECO:0000269	PubMed:23666762
Cytoplasm	ECO:0000269	PubMed:23666762
Cytoplasm, cytoskeleton	ECO:0000250

Summary of Q9P0L2

Gene: MARK1, KIAA1477, MARK
Protein: Serine/threonine-protein kinase MARK1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9P0L2

Gene: MARK1, KIAA1477, MARK Protein: Serine/threonine-protein kinase MARK1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: MARK1, KIAA1477, MARK
Protein: Serine/threonine-protein kinase MARK1