MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q9UBP6

Gene: METTL1, C12orf1
Protein: tRNA (guanine-N(7)-)-methyltransferase

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
2.1.1.-	Transferases; Transferring one-carbon groups; Methyltransferases;
2.1.1.33	Transferases; Transferring one-carbon groups; Methyltransferases; tRNA (guanine46-N7)-methyltransferase

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Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
3CKK	1.55	Crystal structure of human methyltransferase-like protein 1
7OGJ	1.59	Crystal structure of human METTL1 in complex with SAH
7PL1	1.85	Crystal structure of human METTL1 bound to Sinefungin
7U20	3.1	Crystal structure of human METTL1 and WDR4 complex
8CTH	3.3	Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex
8CTI	3.6	Cryo-EM structure of human METTL1-WDR4-tRNA(Val) complex
8D58	2.47	Crystal structure of human METTL1-WDR4 complex
8D59	2.26	Crystal structure of human METTL1 in complex with SAM
8D5B	1.93	Crystal structure of human METTL1 in complex with SAH
8D9K	3.72	CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA

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GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease