Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.1.1.79
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
glyoxylate reductase (NADP+)
1.1.1.81
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
hydroxypyruvate reductase
PDB | Resolution (Å) | PDB name |
---|---|---|
2GCG | 2.2 | Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase |
2H1S | 2.45 | Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens |
2Q50 | 2.45 | Ensemble refinement of the protein crystal structure of a glyoxylate/hydroxypyruvate reductase from Homo sapiens |
2WWR | 2.82 | Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0019752 | carboxylic acid metabolic process |
Biological Process | GO:0043648 | dicarboxylic acid metabolic process |
Biological Process | GO:0046487 | glyoxylate metabolic process |
Molecular Function | GO:0051287 | NAD binding |
Molecular Function | GO:0070402 | NADPH binding |
Molecular Function | GO:0031406 | carboxylic acid binding |
Molecular Function | GO:0008465 | glycerate dehydrogenase activity |
Molecular Function | GO:0030267 | glyoxylate reductase (NADP+) activity |
Molecular Function | GO:0016618 | hydroxypyruvate reductase activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Cellular Component | GO:1902494 | catalytic complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005782 | peroxisomal matrix |
InterPro | InterPro name |
---|---|
IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
IPR036291 | NAD(P)-binding domain superfamily |
Pfam | Pfam name |
---|---|
PF00389 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
PF02826 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-389661 | Glyoxylate metabolism and glycine degradation | Internal node | R-HSA-1430728 | Metabolism |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000010 | Recurrent urinary tract infections |
HP:0000083 | Renal insufficiency |
HP:0000121 | Nephrocalcinosis |
HP:0000787 | Nephrolithiasis |
HP:0000790 | Hematuria |
HP:0003159 | Hyperoxaluria |
HP:0006000 | Ureteral obstruction |
HP:0008672 | Calcium oxalate nephrolithiasis |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
primary hyperoxaluria type 2 | MONDO:0009824 | E74 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:260000 | Orphanet:93599 |