Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.1.1.79
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
glyoxylate reductase (NADP+)
1.1.1.81
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
hydroxypyruvate reductase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2GCG | 2.2 | Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase |
| 2H1S | 2.45 | Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens |
| 2Q50 | 2.45 | Ensemble refinement of the protein crystal structure of a glyoxylate/hydroxypyruvate reductase from Homo sapiens |
| 2WWR | 2.82 | Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0043648 | dicarboxylic acid metabolic process |
| Biological Process | GO:0046487 | glyoxylate metabolic process |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0070402 | NADPH binding |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0008465 | glycerate dehydrogenase activity |
| Molecular Function | GO:0030267 | glyoxylate reductase (NADP+) activity |
| Molecular Function | GO:0016618 | hydroxypyruvate reductase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| InterPro
|
InterPro name |
|---|---|
| IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| IPR036291 | NAD(P)-binding domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00389 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| PF02826 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | Internal node | R-HSA-1430728 | Metabolism |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000083 | Renal insufficiency |
| HP:0000121 | Nephrocalcinosis |
| HP:0000787 | Nephrolithiasis |
| HP:0000790 | Hematuria |
| HP:0003159 | Hyperoxaluria |
| HP:0006000 | Ureteral obstruction |
| HP:0008672 | Calcium oxalate nephrolithiasis |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| primary hyperoxaluria type 2 | MONDO:0009824 | E74 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:260000 | Orphanet:93599 |