Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.4.1.-
Transferases;
Glycosyltransferases;
Hexosyltransferases;
2.4.1.274
Transferases;
Glycosyltransferases;
Hexosyltransferases;
glucosylceramide β-1,4-galactosyltransferase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0022010 | central nervous system myelination |
| Biological Process | GO:0021955 | central nervous system neuron axonogenesis |
| Biological Process | GO:0010706 | ganglioside biosynthetic process via lactosylceramide |
| Biological Process | GO:0006688 | glycosphingolipid biosynthetic process |
| Biological Process | GO:0001572 | lactosylceramide biosynthetic process |
| Biological Process | GO:0042551 | neuron maturation |
| Biological Process | GO:0006486 | protein glycosylation |
| Molecular Function | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity |
| Molecular Function | GO:0008378 | galactosyltransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Cellular Component | GO:0032580 | Golgi cisterna membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR003859 | Beta-1,4-galactosyltransferase |
| IPR027791 | Galactosyltransferase, C-terminal |
| IPR027995 | Galactosyltransferase, N-terminal |
| IPR029044 | Nucleotide-diphospho-sugar transferases |
| Pfam
|
Pfam name |
|---|---|
| PF02709 | N-terminal domain of galactosyltransferase |
| PF13733 | N-terminal region of glycosyl transferase group 7 |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2022854 | Keratan sulfate biosynthesis | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-913709 | O-linked glycosylation of mucins | Internal node | R-HSA-392499 | Metabolism of proteins |
| R-HSA-975577 | N-Glycan antennae elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Golgi apparatus, Golgi stack membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | High | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|