Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.4.2.-
Transferases;
Glycosyltransferases;
Pentosyltransferases;
2.4.2.30
Transferases;
Glycosyltransferases;
Pentosyltransferases;
NAD+ ADP-ribosyltransferase
PDB | Resolution (Å) | PDB name |
---|---|---|
3KCZ | 2.0 | Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide |
3KJD | 1.95 | Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor ABT-888 |
4PJV | 2.5 | Structure of PARP2 catalytic domain bound to inhibitor BMN 673 |
4TVJ | 2.1 | HUMAN ARTD2 (PARP2) - CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB |
4ZZX | 1.65 | Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor |
4ZZY | 2.2 | Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor |
5D5K | 1.9 | Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB |
5DSY | 2.7 | Crystal structure of constitutively active PARP-2 |
6F1K | 2.2 | Structure of ARTD2/PARP2 WGR domain bound to double strand DNA without 5'phosphate |
6F5B | 2.8 | Structure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphate |
6F5F | 2.98 | Structure of ARTD2/PARP2 WGR domain bound to double strand DNA with 5 nucleotide overhang and 5'phosphate |
6TX3 | 2.96 | HPF1 bound to catalytic fragment of PARP2 |
6USJ | 10.5 | Structure of two nucleosomes bridged by human PARP2 |
6X0L | 3.9 | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin |
6X0M | 6.3 | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin |
6X0N | 10.0 | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin |
7AEO | 2.8 | Human ARTD2 in complex with DNA oligonucleotides |
7R59 | 2.0 | PARP2 catalytic domain in complex with OUL245 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0030592 | DNA ADP-ribosylation |
Biological Process | GO:0006974 | DNA damage response |
Biological Process | GO:0006281 | DNA repair |
Biological Process | GO:0140861 | DNA repair-dependent chromatin remodeling |
Biological Process | GO:0006284 | base-excision repair |
Biological Process | GO:0046697 | decidualization |
Biological Process | GO:0006302 | double-strand break repair |
Biological Process | GO:0097191 | extrinsic apoptotic signaling pathway |
Biological Process | GO:1901215 | negative regulation of neuron death |
Biological Process | GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development |
Biological Process | GO:0070213 | protein auto-ADP-ribosylation |
Biological Process | GO:0070212 | protein poly-ADP-ribosylation |
Molecular Function | GO:0140294 | NAD DNA ADP-ribosyltransferase activity |
Molecular Function | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
Molecular Function | GO:0140806 | NAD+- protein-aspartate ADP-ribosyltransferase activity |
Molecular Function | GO:1990404 | NAD+-protein ADP-ribosyltransferase activity |
Molecular Function | GO:0140807 | NAD+-protein-glutamate ADP-ribosyltransferase activity |
Molecular Function | GO:0140805 | NAD+-protein-serine ADP-ribosyltransferase activity |
Molecular Function | GO:0003682 | chromatin binding |
Molecular Function | GO:0003684 | damaged DNA binding |
Molecular Function | GO:0031491 | nucleosome binding |
Molecular Function | GO:0016779 | nucleotidyltransferase activity |
Molecular Function | GO:0072572 | poly-ADP-D-ribose binding |
Molecular Function | GO:0160004 | poly-ADP-D-ribose modification-dependent protein binding |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0090734 | site of DNA damage |
InterPro | InterPro name |
---|---|
IPR004102 | Poly(ADP-ribose) polymerase, regulatory domain |
IPR008893 | WGR domain |
IPR012317 | Poly(ADP-ribose) polymerase, catalytic domain |
IPR036616 | Poly(ADP-ribose) polymerase, regulatory domain superfamily |
IPR036930 | WGR domain superfamily |
Pfam | Pfam name |
---|---|
PF00644 | Poly(ADP-ribose) polymerase catalytic domain |
PF02877 | Poly(ADP-ribose) polymerase, regulatory domain |
PF05406 | WGR domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-5696400 | Dual Incision in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
Location | ECO term | Pubmed |
---|---|---|
Chromosome | ECO:0000269 | PubMed:26704974 |
Chromosome | ECO:0000269 | PubMed:30104678 |
Chromosome | ECO:0000269 | PubMed:30321391 |
Chromosome | ECO:0000269 | PubMed:32939087 |
Chromosome | ECO:0000269 | PubMed:33141820 |
Chromosome | ECO:0000269 | PubMed:35349716 |
Nucleus | ECO:0000269 | PubMed:10364231 |
Nucleus | ECO:0000269 | PubMed:26704974 |