MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.6.1.15	Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides; nucleoside-triphosphate phosphatase
3.6.4.13	Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement; RNA helicase

PDB	Resolution (Å)	PDB name
2OXC	1.3	Human DEAD-box RNA helicase DDX20, DEAD domain in complex with ADP
3B7G	1.9	Human DEAD-box RNA helicase DDX20, Conserved domain I (DEAD) in complex with AMPPNP (Adenosine-(Beta,gamma)-imidotriphosphate)

GO ontology	GO term	GO description
Biological Process	GO:0006396	RNA processing
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0048477	oogenesis
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0050810	regulation of steroid biosynthetic process
Biological Process	GO:0000387	spliceosomal snRNP assembly
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003724	RNA helicase activity
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Cellular Component	GO:0097504	Gemini of coiled bodies
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex
Cellular Component	GO:0032797	SMN complex
Cellular Component	GO:0034719	SMN-Sm protein complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro	InterPro name
IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
IPR001650	Helicase, C-terminal
IPR011545	DEAD/DEAH box helicase domain
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR014014	RNA helicase, DEAD-box type, Q motif
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Pfam	Pfam name
PF00270	DEAD/DEAH box helicase
PF00271	Helicase conserved C-terminal domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-191859	snRNP Assembly	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	Leaf	R-HSA-1643685	Disease

Tissue	Cell type	Expression level	Reliability
appendix	lymphoid tissue	Low	Enhanced
breast	glandular cells	Low	Enhanced
bronchus	respiratory epithelial cells	Low	Enhanced
colon	glandular cells	Low	Enhanced
colon	peripheral nerve/ganglion	Low	Enhanced
duodenum	glandular cells	Low	Enhanced
endometrium 1	glandular cells	Low	Enhanced
epididymis	glandular cells	Low	Enhanced
esophagus	squamous epithelial cells	Low	Enhanced
fallopian tube	glandular cells	Low	Enhanced
lymph node	germinal center cells	Low	Enhanced
ovary	follicle cells	Medium	Enhanced
rectum	glandular cells	Low	Enhanced
small intestine	glandular cells	Low	Enhanced
stomach 1	glandular cells	Low	Enhanced
testis	round or early spermatids	Medium	Enhanced
tonsil	germinal center cells	Low	Enhanced
tonsil	non-germinal center cells	Low	Enhanced
urinary bladder	urothelial cells	Low	Enhanced