Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.2.2
Transferases;
Acyltransferases;
Aminoacyltransferases;
γ-glutamyltransferase
3.4.19.13
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases;
glutathione γ-glutamate hydrolase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006750 | glutathione biosynthetic process |
| Biological Process | GO:0006751 | glutathione catabolic process |
| Biological Process | GO:1901750 | leukotriene D4 biosynthetic process |
| Biological Process | GO:1902883 | negative regulation of response to oxidative stress |
| Molecular Function | GO:0036374 | glutathione hydrolase activity |
| Molecular Function | GO:0102953 | hypoglycin A gamma-glutamyl transpeptidase activity |
| Molecular Function | GO:0103068 | leukotriene C4 gamma-glutamyl transferase activity |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-174403 | Glutathione synthesis and recycling | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-5423646 | Aflatoxin activation and detoxification | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9753281 | Paracetamol ADME | Leaf | R-HSA-9748784 | Drug ADME |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Approved |
| appendix | glandular cells | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | High | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | High | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | High | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | High | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Low | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|