MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2EC1		Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa
3TJ3	2.702	Structure of importin a5 bound to the N-terminus of Nup50
7MO0	2.45	Crystal Structure of Nucleoporin NUP50 Ran-Binding Domain in Complex with Ran-GPPNHP

GO term

GO ontology	GO term	GO description
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0006606	protein import into nucleus
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR000156	Ran binding domain
IPR011993	PH-like domain superfamily
IPR015007	Nuclear pore complex, NUP2/50/61
IPR045255	Ran binding protein RanBP1-like

Pfam	Pfam name
PF00638	RanBP1 domain
PF08911	NUP50 (Nucleoporin 50 kDa)

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-159227	Transport of the SLBP independent Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	Leaf	R-HSA-1643685	Disease
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	Leaf	R-HSA-1643685	Disease
R-HSA-168276	NS1 Mediated Effects on Host Pathways	Internal node	R-HSA-1643685	Disease
R-HSA-168325	Viral Messenger RNA Synthesis	Leaf	R-HSA-1643685	Disease
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	Leaf	R-HSA-1643685	Disease
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	Leaf	R-HSA-1430728	Metabolism
R-HSA-180746	Nuclear import of Rev protein	Leaf	R-HSA-1643685	Disease
R-HSA-180910	Vpr-mediated nuclear import of PICs	Leaf	R-HSA-1643685	Disease
R-HSA-191859	snRNP Assembly	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-4085377	SUMOylation of SUMOylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4551638	SUMOylation of chromatin organization proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4570464	SUMOylation of RNA binding proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4615885	SUMOylation of DNA replication proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5578749	Transcriptional regulation by small RNAs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Leaf	R-HSA-1643685	Disease
R-HSA-6784531	tRNA processing in the nucleus	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-9609690	HCMV Early Events	Leaf	R-HSA-1643685	Disease
R-HSA-9610379	HCMV Late Events	Leaf	R-HSA-1643685	Disease
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus membrane	ECO:0000250
Nucleus, nuclear pore complex	ECO:0000269	PubMed:12802065

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
adrenal gland	glandular cells	Medium	Enhanced
appendix	glandular cells	High	Enhanced
appendix	lymphoid tissue	High	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	High	Enhanced
breast	myoepithelial cells	Medium	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	Medium	Enhanced
caudate	neuronal cells	High	Enhanced
cerebellum	Purkinje cells	High	Enhanced
cerebellum	cells in granular layer	Medium	Enhanced
cerebellum	cells in molecular layer	Medium	Enhanced
cerebral cortex	endothelial cells	Medium	Enhanced
cerebral cortex	glial cells	Medium	Enhanced
cerebral cortex	neuronal cells	High	Enhanced
cerebral cortex	neuropil	Low	Enhanced
cervix	glandular cells	High	Enhanced
cervix	squamous epithelial cells	High	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	glandular cells	High	Enhanced
duodenum	glandular cells	High	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 1	glandular cells	High	Enhanced
endometrium 2	cells in endometrial stroma	Medium	Enhanced
endometrium 2	glandular cells	High	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	High	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
hippocampus	glial cells	Medium	Enhanced
hippocampus	neuronal cells	High	Enhanced
kidney	cells in glomeruli	High	Enhanced
kidney	cells in tubules	High	Enhanced
liver	cholangiocytes	Low	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells type I	High	Enhanced
lung	alveolar cells type II	High	Enhanced
lung	endothelial cells	Medium	Enhanced
lung	macrophages	High	Enhanced
lymph node	non-germinal center cells	High	Enhanced
nasopharynx	respiratory epithelial cells	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
ovary	follicle cells	High	Enhanced
ovary	ovarian stroma cells	Medium	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
pancreas	pancreatic endocrine cells	High	Enhanced
parathyroid gland	glandular cells	Medium	Enhanced
placenta	decidual cells	High	Enhanced
placenta	trophoblastic cells	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	glandular cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skeletal muscle	myocytes	Low	Enhanced
skin 1	Langerhans	High	Enhanced
skin 1	fibroblasts	High	Enhanced
skin 1	keratinocytes	High	Enhanced
skin 1	melanocytes	High	Enhanced
skin 2	epidermal cells	High	Enhanced
small intestine	glandular cells	High	Enhanced
smooth muscle	smooth muscle cells	Medium	Enhanced
soft tissue 1	chondrocytes	Medium	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 1	peripheral nerve	Medium	Enhanced
soft tissue 2	fibroblasts	High	Enhanced
soft tissue 2	peripheral nerve	Medium	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	Medium	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	elongated or late spermatids	Medium	Enhanced
testis	pachytene spermatocytes	Low	Enhanced
testis	peritubular cells	Medium	Enhanced
testis	preleptotene spermatocytes	Medium	Enhanced
testis	sertoli cells	High	Enhanced
testis	spermatogonia cells	Medium	Enhanced
thyroid gland	glandular cells	Medium	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Disease

Summary of Q9UKX7

Gene: NUP50, NPAP60L, PRO1146
Protein: Nuclear pore complex protein Nup50

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9UKX7

Gene: NUP50, NPAP60L, PRO1146 Protein: Nuclear pore complex protein Nup50

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: NUP50, NPAP60L, PRO1146
Protein: Nuclear pore complex protein Nup50