Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.3.16
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-serine/threonine phosphatase
3.1.3.48
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-tyrosine-phosphatase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007049 | cell cycle |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0032467 | positive regulation of cytokinesis |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0007096 | regulation of exit from mitosis |
| Biological Process | GO:0007605 | sensory perception of sound |
| Molecular Function | GO:0017018 | myosin phosphatase activity |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:1902636 | kinociliary basal body |
| Cellular Component | GO:0060091 | kinocilium |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000922 | spindle pole |
| Cellular Component | GO:0032426 | stereocilium tip |
| InterPro
|
InterPro name |
|---|---|
| IPR000340 | Dual specificity phosphatase, catalytic domain |
| IPR000387 | Tyrosine-specific protein phosphatases domain |
| IPR003595 | Protein-tyrosine phosphatase, catalytic |
| IPR016130 | Protein-tyrosine phosphatase, active site |
| IPR020422 | Dual specificity protein phosphatase domain |
| IPR029021 | Protein-tyrosine phosphatase-like |
| IPR029260 | Dual specificity/tyrosine protein phosphatase, N-terminal |
| IPR044506 | Dual-specificity phosphatase CDC14, C-terminal |
| Pfam
|
Pfam name |
|---|---|
| PF00782 | Dual specificity phosphatase, catalytic domain |
| PF14671 | Dual specificity protein phosphatase, N-terminal half |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | Leaf | R-HSA-162582 | Signal Transduction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell projection, kinocilium | ECO:0000250 | |
| Cell projection, stereocilium | ECO:0000250 | |
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:11901424 |
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:12134069 |
| Cytoplasm, cytoskeleton, spindle | ECO:0000269 | PubMed:15263015 |
| Cytoplasm, cytoskeleton, spindle pole | ECO:0000269 | PubMed:11901424 |
| Cytoplasm, cytoskeleton, spindle pole | ECO:0000269 | PubMed:15263015 |
| Nucleus | ECO:0000269 | PubMed:9367992 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000407 | Sensorineural hearing impairment |
| HP:0003251 | Male infertility |
| HP:0003577 | Congenital onset |
| HP:0012208 | Immotile sperm |
| HP:0012864 | Abnormal sperm morphology |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | ciliated cells (cell body) | Low | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | ciliated cells (cell body) | Low | Approved |
| fallopian tube | non-ciliated cells | Low | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells type I | High | Approved |
| lung | alveolar cells type II | High | Approved |
| lung | endothelial cells | Medium | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | basal cells | Medium | Approved |
| nasopharynx | ciliated cells (cell body) | High | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | High | Approved |
| testis | preleptotene spermatocytes | Low | Approved |
| testis | spermatogonia cells | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| autosomal recessive nonsyndromic hearing loss 32 | MONDO:0012091 | H90 | chapter8, Diseases of the ear and mastoid process | OMIM:608653 |