Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.3.62
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
multiple inositol-polyphosphate phosphatase
3.1.3.80
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
2,3-bisphosphoglycerate 3-phosphatase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0030282 | bone mineralization |
| Biological Process | GO:0043647 | inositol phosphate metabolic process |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0006797 | polyphosphate metabolic process |
| Molecular Function | GO:0003993 | acid phosphatase activity |
| Molecular Function | GO:0034417 | bisphosphoglycerate 3-phosphatase activity |
| Molecular Function | GO:0052826 | inositol hexakisphosphate 2-phosphatase activity |
| Molecular Function | GO:0052745 | inositol phosphate phosphatase activity |
| Molecular Function | GO:0030351 | inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity |
| Molecular Function | GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
| Molecular Function | GO:0101006 | protein histidine phosphatase activity |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1855231 | Synthesis of IPs in the ER lumen | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Endoplasmic reticulum lumen | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000028 | Cryptorchidism |
| HP:0000054 | Micropenis |
| HP:0000062 | Ambiguous genitalia |
| HP:0000133 | Gonadal dysgenesis |
| HP:0000151 | Aplasia of the uterus |
| HP:0000215 | Thick upper lip vermilion |
| HP:0000218 | High palate |
| HP:0000252 | Microcephaly |
| HP:0000286 | Epicanthus |
| HP:0000347 | Micrognathia |
| HP:0000369 | Low-set ears |
| HP:0000400 | Macrotia |
| HP:0000431 | Wide nasal bridge |
| HP:0000448 | Prominent nose |
| HP:0000508 | Ptosis |
| HP:0000518 | Cataract |
| HP:0000582 | Upslanted palpebral fissure |
| HP:0000639 | Nystagmus |
| HP:0000648 | Optic atrophy |
| HP:0000853 | Goiter |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001257 | Spasticity |
| HP:0001263 | Global developmental delay |
| HP:0001276 | Hypertonia |
| HP:0001321 | Cerebellar hypoplasia |
| HP:0001336 | Myoclonus |
| HP:0001344 | Absent speech |
| HP:0001347 | Hyperreflexia |
| HP:0001428 | Somatic mutation |
| HP:0002015 | Dysphagia |
| HP:0002060 | Abnormal cerebral morphology |
| HP:0002071 | Abnormality of extrapyramidal motor function |
| HP:0002079 | Hypoplasia of the corpus callosum |
| HP:0002104 | Apnea |
| HP:0002119 | Ventriculomegaly |
| HP:0002120 | Cerebral cortical atrophy |
| HP:0002176 | Spinal cord compression |
| HP:0002194 | Delayed gross motor development |
| HP:0002365 | Hypoplasia of the brainstem |
| HP:0002380 | Fasciculations |
| HP:0002500 | Abnormal cerebral white matter morphology |
| HP:0002509 | Limb hypertonia |
| HP:0002510 | Spastic tetraplegia |
| HP:0002650 | Scoliosis |
| HP:0002653 | Bone pain |
| HP:0002730 | Chronic noninfectious lymphadenopathy |
| HP:0002733 | Abnormal lymph node morphology |
| HP:0002757 | Recurrent fractures |
| HP:0002895 | Papillary thyroid carcinoma |
| HP:0003003 | Colon cancer |
| HP:0003202 | Skeletal muscle atrophy |
| HP:0003623 | Neonatal onset |
| HP:0004305 | Involuntary movements |
| HP:0005280 | Depressed nasal bridge |
| HP:0005994 | Nodular goiter |
| HP:0006528 | Chronic lung disease |
| HP:0006731 | Follicular thyroid carcinoma |
| HP:0006766 | Papillary renal cell carcinoma |
| HP:0006955 | Olivopontocerebellar hypoplasia |
| HP:0008665 | Clitoral hypertrophy |
| HP:0008936 | Axial hypotonia |
| HP:0010862 | Delayed fine motor development |
| HP:0012110 | Hypoplasia of the pons |
| HP:0012288 | Neoplasm of head and neck |
| HP:0012531 | Pain |
| HP:0012856 | Abnormal scrotal rugation |
| HP:0030197 | Fatigable weakness of skeletal muscles |
| HP:0030260 | Microphallus |
| HP:0030261 | Absent penis |
| HP:0030674 | Antenatal onset |
| HP:0033725 | Thin corpus callosum |
| HP:0040198 | Non-medullary thyroid carcinoma |
| HP:3000037 | Abnormal neck blood vessel morphology |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| thyroid gland | glandular cells | Low | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| thyroid cancer, nonmedullary, 2 | MONDO:0008566 | C73 | chapter2, Neoplasms | OMIM:188470 |