Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
3.1.1.4
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A2
3.1.1.5
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
lysophospholipase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019369 | arachidonic acid metabolic process |
| Biological Process | GO:0046475 | glycerophospholipid catabolic process |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0140042 | lipid droplet formation |
| Biological Process | GO:0007567 | parturition |
| Biological Process | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| Biological Process | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling |
| Biological Process | GO:0006644 | phospholipid metabolic process |
| Biological Process | GO:0006663 | platelet activating factor biosynthetic process |
| Molecular Function | GO:0008374 | O-acyltransferase activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0047498 | calcium-dependent phospholipase A2 activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0047499 | calcium-independent phospholipase A2 activity |
| Molecular Function | GO:0004622 | lysophospholipase activity |
| Molecular Function | GO:0102545 | phosphatidyl phospholipase B activity |
| Molecular Function | GO:0008970 | phospholipase A1 activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1482788 | Acyl chain remodelling of PC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482839 | Acyl chain remodelling of PE | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482922 | Acyl chain remodelling of PI | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1483115 | Hydrolysis of LPC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1483152 | Hydrolysis of LPE | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:10085124 |
| Cell membrane | ECO:0000269 | PubMed:14529291 |
| Cell membrane | ECO:0000269 | PubMed:9705332 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:15944408 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:19501189 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:28336330 |
| Lipid droplet | ECO:0000269 | PubMed:28336330 |
| Mitochondrion membrane | ECO:0000269 | PubMed:15944408 |
| Mitochondrion membrane | ECO:0000269 | PubMed:19501189 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | High | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | High | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 2 | chondrocytes | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| spleen | cells in red pulp | High | Approved |
| spleen | cells in white pulp | High | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | High | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|