Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.14.11.27
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
[histone H3]-dimethyl-L-lysine36 demethylase
1.14.11.65
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor;
[histone H3]-dimethyl-L-lysine9 demethylase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2WWU | 2.15 | Crystal structure of the catalytic domain of PHD finger protein 8 |
| 3K3N | 2.4 | Crystal structure of the catalytic core domain of human PHF8 |
| 3K3O | 2.1 | Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate |
| 3KV4 | 2.19 | Structure of PHF8 in complex with histone H3 |
| 4DO0 | 2.55 | Crystal Structure of human PHF8 in complex with Daminozide |
| 7CMZ | 1.695 | Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0061188 | negative regulation of rDNA heterochromatin formation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045943 | positive regulation of transcription by RNA polymerase I |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006482 | protein demethylation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Molecular Function | GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0071558 | histone H3K27me2/H3K27me3 demethylase activity |
| Molecular Function | GO:0051864 | histone H3K36 demethylase activity |
| Molecular Function | GO:0140680 | histone H3K36me/H3K36me2 demethylase activity |
| Molecular Function | GO:0032454 | histone H3K9 demethylase activity |
| Molecular Function | GO:0140683 | histone H3K9me/H3K9me2 demethylase activity |
| Molecular Function | GO:0035575 | histone H4K20 demethylase activity |
| Molecular Function | GO:0032452 | histone demethylase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0035064 | methylated histone binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR001965 | Zinc finger, PHD-type |
| IPR003347 | JmjC domain |
| IPR011011 | Zinc finger, FYVE/PHD-type |
| IPR019786 | Zinc finger, PHD-type, conserved site |
| IPR019787 | Zinc finger, PHD-finger |
| IPR041070 | Jumonji, helical domain |
| Pfam
|
Pfam name |
|---|---|
| PF00628 | PHD-finger |
| PF02373 | JmjC domain, hydroxylase |
| PF17811 | Jumonji helical domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2299718 | Condensation of Prophase Chromosomes | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-3214842 | HDMs demethylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000269 | PubMed:19843542 |
| Nucleus | ECO:0000269 | PubMed:20622854 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:20208542 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:20531378 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000028 | Cryptorchidism |
| HP:0000175 | Cleft palate |
| HP:0000202 | Orofacial cleft |
| HP:0000204 | Cleft upper lip |
| HP:0000252 | Microcephaly |
| HP:0000276 | Long face |
| HP:0000336 | Prominent supraorbital ridges |
| HP:0000340 | Sloping forehead |
| HP:0000455 | Broad nasal tip |
| HP:0000582 | Upslanted palpebral fissure |
| HP:0000664 | Synophrys |
| HP:0000750 | Delayed speech and language development |
| HP:0001166 | Arachnodactyly |
| HP:0001176 | Large hands |
| HP:0001177 | Preaxial hand polydactyly |
| HP:0001249 | Intellectual disability |
| HP:0001256 | Intellectual disability, mild |
| HP:0001419 | X-linked recessive inheritance |
| HP:0001611 | Hypernasal speech |
| HP:0001763 | Pes planus |
| HP:0002162 | Low posterior hairline |
| HP:0002650 | Scoliosis |
| HP:0002942 | Thoracic kyphosis |
| HP:0008734 | Decreased testicular size |
| HP:0010511 | Long toe |
| HP:0410030 | Cleft lip |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| syndromic x-linked intellectual disability siderius type | MONDO:0010286 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:300263 | Orphanet:85287 |