Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.1.15
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
nucleoside-triphosphate phosphatase
3.6.1.42
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
guanosine-diphosphatase
3.6.1.6
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
nucleoside diphosphate phosphatase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 6WG5 | 2.6 | Human ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4, NTPDase 4) |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0046036 | CTP metabolic process |
| Biological Process | GO:0046712 | GDP catabolic process |
| Biological Process | GO:0006256 | UDP catabolic process |
| Biological Process | GO:0034656 | nucleobase-containing small molecule catabolic process |
| Molecular Function | GO:0036384 | CDP phosphatase activity |
| Molecular Function | GO:0043273 | CTPase activity |
| Molecular Function | GO:0004382 | GDP phosphatase activity |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0045134 | UDP phosphatase activity |
| Molecular Function | GO:0017110 | nucleoside diphosphate phosphatase activity |
| Molecular Function | GO:0017111 | ribonucleoside triphosphate phosphatase activity |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-8850843 | Phosphate bond hydrolysis by NTPDase proteins | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasmic vesicle, autophagosome membrane | ECO:0000269 | PubMed:10393803 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:9556635 |
| Lysosome membrane | ECO:0000269 | PubMed:10393803 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Supported |
| appendix | endocrine cells | High | Supported |
| appendix | enterocytes | High | Supported |
| appendix | germinal center cells | High | Supported |
| appendix | goblet cells | High | Supported |
| appendix | non-germinal center cells | Medium | Supported |
| breast | glandular cells | Medium | Supported |
| bronchus | basal cells | Medium | Supported |
| bronchus | ciliated cells (cell body) | High | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | High | Supported |
| cerebellum | cells in molecular layer | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| colon | endocrine cells | High | Supported |
| colon | enterocytes | High | Supported |
| colon | goblet cells | High | Supported |
| colon | mucosal lymphoid cells | High | Supported |
| duodenum | endocrine cells | High | Supported |
| duodenum | enterocytes | High | Supported |
| duodenum | goblet cells | High | Supported |
| duodenum | paneth cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Low | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | Low | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | High | Supported |
| fallopian tube | ciliated cells (cell body) | High | Supported |
| fallopian tube | ciliated cells (ciliary rootlets) | Low | Supported |
| gallbladder | glandular cells | High | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | cells in tubules | Low | Supported |
| lung | macrophages | Low | Supported |
| lymph node | germinal center cells | High | Supported |
| lymph node | non-germinal center cells | High | Supported |
| nasopharynx | basal cells | High | Supported |
| nasopharynx | ciliated cells (cell body) | High | Supported |
| ovary | follicle cells | Medium | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | Medium | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | High | Supported |
| rectum | endocrine cells | High | Supported |
| rectum | enterocytes | High | Supported |
| rectum | goblet cells | High | Supported |
| rectum | mucosal lymphoid cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | Low | Supported |
| skin 1 | melanocytes | High | Supported |
| small intestine | endocrine cells | High | Supported |
| small intestine | enterocytes | High | Supported |
| small intestine | goblet cells | High | Supported |
| small intestine | paneth cells | High | Supported |
| spleen | cells in red pulp | High | Supported |
| spleen | cells in white pulp | High | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | cells in seminiferous ducts | High | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | High | Supported |
| tonsil | non-germinal center cells | High | Supported |
| tonsil | squamous epithelial cells | Low | Supported |
| urinary bladder | urothelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|